Names & Taxonomy

Uniprot ID:
P24385
Entry Name:
CCND1_HUMAN
Status:
reviewed
Protein Names:
G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein) (BCL-1) (BCL-1 oncogene) (PRAD1 oncogene)
Gene Names:
CCND1 BCL1 PRAD1
Gene Names Primary:
CCND1
Organism:
Homo sapiens (Human)

Structure

Length:
295
Sequence:
MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRKHAQTFVALCATDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCDPDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Nucleus

Function

Function:
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.
Cross Reference Drug Bank:
DB01169
Gene Ontology Go:
bicellular tight junction
cyclin-dependent protein kinase holoenzyme complex
cytosol
intracellular
membrane
nucleoplasm
nucleus
transcriptional repressor complex
cyclin-dependent protein serine/threonine kinase regulator activity
enzyme binding
histone deacetylase binding
proline-rich region binding
protein kinase activity
protein kinase binding
transcription corepressor activity
transcription factor binding
canonical Wnt signaling pathway
cell division
cellular response to DNA damage stimulus
chromatin organization
endoplasmic reticulum unfolded protein response
fat cell differentiation
G1/S transition of mitotic cell cycle
lactation
Leydig cell differentiation
liver regeneration
mammary gland alveolus development
mammary gland epithelial cell proliferation
mitotic cell cycle
mitotic G1 DNA damage checkpoint
negative regulation of cell cycle arrest
negative regulation of epithelial cell differentiation
negative regulation of transcription from RNA polymerase II promoter
negative regulation of Wnt signaling pathway
Notch signaling pathway
positive regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of G2/M transition of mitotic cell cycle
positive regulation of mammary gland epithelial cell proliferation
positive regulation of protein phosphorylation
re-entry into mitotic cell cycle
response to calcium ion
response to corticosterone
response to drug
response to estradiol
response to ethanol
response to iron ion
response to leptin
response to magnesium ion
response to organonitrogen compound
response to UV-A
response to vitamin E
response to X-ray
transcription, DNA-templated
Gene Ontology Biological Process:
canonical Wnt signaling pathway
cell division
cellular response to DNA damage stimulus
chromatin organization
endoplasmic reticulum unfolded protein response
fat cell differentiation
G1/S transition of mitotic cell cycle
lactation
Leydig cell differentiation
liver regeneration
mammary gland alveolus development
mammary gland epithelial cell proliferation
mitotic cell cycle
mitotic G1 DNA damage checkpoint
negative regulation of cell cycle arrest
negative regulation of epithelial cell differentiation
negative regulation of transcription from RNA polymerase II promoter
negative regulation of Wnt signaling pathway
Notch signaling pathway
positive regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of G2/M transition of mitotic cell cycle
positive regulation of mammary gland epithelial cell proliferation
positive regulation of protein phosphorylation
re-entry into mitotic cell cycle
response to calcium ion
response to corticosterone
response to drug
response to estradiol
response to ethanol
response to iron ion
response to leptin
response to magnesium ion
response to organonitrogen compound
response to UV-A
response to vitamin E
response to X-ray
transcription, DNA-templated
Gene Ontology Molecular Function:
cyclin-dependent protein serine/threonine kinase regulator activity
enzyme binding
histone deacetylase binding
proline-rich region binding
protein kinase activity
protein kinase binding
transcription corepressor activity
transcription factor binding
Gene Ontology Cellular Component:
bicellular tight junction
cyclin-dependent protein kinase holoenzyme complex
cytosol
intracellular
membrane
nucleoplasm
nucleus
transcriptional repressor complex
Keywords:
3D-structure
Cell cycle
Cell division
Chromosomal rearrangement
Complete proteome
Cyclin
Cytoplasm
DNA damage
Isopeptide bond
Membrane
Nucleus
Phosphoprotein
Proto-oncogene
Reference proteome
Repressor
Transcription
Transcription regulation
Ubl conjugation
Interacts With:
Q96TE0; P38398; P24941; P11802; P30285; Q00534; P38936; P46527; Q62796; Q96PU4

Publication

PubMed ID:
1826542 1833066 1827756 1833629 8204893 15489334 7687458 8302605 8695815 9106657 10766840 15241418 16569215 18417529 19124461 19917254 19412162 21952639 24275569 19237565