Names & Taxonomy
- Uniprot ID:
- P24347
- Entry Name:
- MMP11_HUMAN
- Status:
- reviewed
- Protein Names:
- Stromelysin-3 (SL-3) (ST3) (EC 3.4.24.-) (Matrix metalloproteinase-11) (MMP-11)
- Gene Names:
- MMP11 STMY3
- Gene Names Primary:
- MMP11
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 488
- Sequence:
- MAPAAWLRSAAARALLPPMLLLLLQPPPLLARALPPDAHHLHAERRGPQPWHAALPSSPAPAPATQEAPRPASSLRPPRCGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLSLSPDDCRGVQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYWVYDGEKPVLGPAPLTELGLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDADGYAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGCAEPANTFL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space, extracellular matrix
Function
- Function:
- May play an important role in the progression of epithelial malignancies.
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Active Site:
- ACT_SITE 216 216
- Cross Reference Drug Bank:
- DB00786
- Gene Ontology Go:
- extracellular region
Golgi lumen
proteinaceous extracellular matrix
calcium ion binding
metalloendopeptidase activity
zinc ion binding
basement membrane organization
collagen catabolic process
collagen fibril organization
extracellular matrix disassembly
extracellular matrix organization
multicellular organism development
negative regulation of fat cell differentiation
proteolysis - Gene Ontology Biological Process:
- basement membrane organization
collagen catabolic process
collagen fibril organization
extracellular matrix disassembly
extracellular matrix organization
multicellular organism development
negative regulation of fat cell differentiation
proteolysis - Gene Ontology Molecular Function:
- calcium ion binding
metalloendopeptidase activity
zinc ion binding - Gene Ontology Cellular Component:
- extracellular region
Golgi lumen
proteinaceous extracellular matrix - Keywords:
- Calcium
Cleavage on pair of basic residues
Collagen degradation
Complete proteome
Direct protein sequencing
Disulfide bond
Extracellular matrix
Hydrolase
Metal-binding
Metalloprotease
Polymorphism
Protease
Reference proteome
Repeat
Secreted
Signal
Zinc
Zymogen