Names & Taxonomy

Uniprot ID:
P24347
Entry Name:
MMP11_HUMAN
Status:
reviewed
Protein Names:
Stromelysin-3 (SL-3) (ST3) (EC 3.4.24.-) (Matrix metalloproteinase-11) (MMP-11)
Gene Names:
MMP11 STMY3
Gene Names Primary:
MMP11
Organism:
Homo sapiens (Human)

Structure

Length:
488
Sequence:
MAPAAWLRSAAARALLPPMLLLLLQPPPLLARALPPDAHHLHAERRGPQPWHAALPSSPAPAPATQEAPRPASSLRPPRCGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLSLSPDDCRGVQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYWVYDGEKPVLGPAPLTELGLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDADGYAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGCAEPANTFL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted, extracellular space, extracellular matrix

Function

Function:
May play an important role in the progression of epithelial malignancies.
Cofactor:
COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
Active Site:
ACT_SITE 216 216
Cross Reference Drug Bank:
DB00786
Gene Ontology Go:
extracellular region
Golgi lumen
proteinaceous extracellular matrix
calcium ion binding
metalloendopeptidase activity
zinc ion binding
basement membrane organization
collagen catabolic process
collagen fibril organization
extracellular matrix disassembly
extracellular matrix organization
multicellular organism development
negative regulation of fat cell differentiation
proteolysis
Gene Ontology Biological Process:
basement membrane organization
collagen catabolic process
collagen fibril organization
extracellular matrix disassembly
extracellular matrix organization
multicellular organism development
negative regulation of fat cell differentiation
proteolysis
Gene Ontology Molecular Function:
calcium ion binding
metalloendopeptidase activity
zinc ion binding
Gene Ontology Cellular Component:
extracellular region
Golgi lumen
proteinaceous extracellular matrix
Keywords:
Calcium
Cleavage on pair of basic residues
Collagen degradation
Complete proteome
Direct protein sequencing
Disulfide bond
Extracellular matrix
Hydrolase
Metal-binding
Metalloprotease
Polymorphism
Protease
Reference proteome
Repeat
Secreted
Signal
Zinc
Zymogen

Publication

PubMed ID:
1701851 10591208 15489334 7657606 7746327 16959974