Names & Taxonomy
- Uniprot ID:
- P23975
- Entry Name:
- SC6A2_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium-dependent noradrenaline transporter (Norepinephrine transporter) (NET) (Solute carrier family 6 member 2)
- Gene Names:
- SLC6A2 NAT1 NET1 SLC6A5
- Gene Names Primary:
- SLC6A2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 617
- Sequence:
- MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHLVAQRDIRQFQLQHWLAI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.
- Cross Reference Drug Bank:
- DB00321 DB00543 DB00182 DB00289 DB01156 DB01114 DB00215 DB01242 DB00907 DB04840 DB01151 DB06700 DB06701 DB01576 DB00514 DB00937 DB00988 DB01142 DB06262 DB00476 DB01363 DB01364 DB00696 DB01175 DB01381 DB00226 DB01170 DB00458 DB06704 DB01221 DB08918 DB06707 DB00408 DB00934 DB00579 DB01577 DB00422 DB06148 DB04896 DB00370 DB01149 DB00368 DB00540 DB01173 DB00715 DB00454 DB01579 DB00830 DB00191 DB00344 DB00852 DB00234 DB01105 DB06204 DB00193 DB00726 DB00285
- Gene Ontology Go:
- integral component of plasma membrane
membrane
neuron projection
plasma membrane
metal ion binding
monoamine transmembrane transporter activity
norepinephrine:sodium symporter activity
monoamine transport
norepinephrine transport
response to pain
synaptic transmission
transmembrane transport
transport - Gene Ontology Biological Process:
- monoamine transport
norepinephrine transport
response to pain
synaptic transmission
transmembrane transport
transport - Gene Ontology Molecular Function:
- metal ion binding
monoamine transmembrane transporter activity
norepinephrine:sodium symporter activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
membrane
neuron projection
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Membrane
Metal-binding
Neurotransmitter transport
Polymorphism
Reference proteome
Sodium
Symport
Transmembrane
Transmembrane helix
Transport