Names & Taxonomy

Uniprot ID:
P23634
Entry Name:
AT2B4_HUMAN
Status:
reviewed
Protein Names:
Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 3.6.3.8) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4)
Gene Names:
ATP2B4 ATP2B2 MXRA1
Gene Names Primary:
ATP2B4
Organism:
Homo sapiens (Human)

Structure

Length:
1241
Sequence:
MTNPSDRVLPANSMAESREGDFGCTVMELRKLMELRSRDALTQINVHYGGVQNLCSRLKTSPVEGLSGNPADLEKRRQVFGHNVIPPKKPKTFLELVWEALQDVTLIILEIAAIISLVLSFYRPAGEENELCGQVATTPEDENEAQAGWIEGAAILFSVIIVVLVTAFNDWSKEKQFRGLQCRIEQEQKFSIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIILTLLGVNEDDEGEKKKKGKKQGVPENRNKAKTQDGVALEIQPLNSQEGIDNEEKDKKAVKVPKKEKSVLQGKLTRLAVQIGKAGLLMSALTVFILILYFVIDNFVINRRPWLPECTPIYIQYFVKFFIIGITVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYIGGIHYRQIPSPDVFLPKVLDLIVNGISINSAYTSKILPPEKEGGLPRQVGNKTECALLGFVTDLKQDYQAVRNEVPEEKLYKVYTFNSVRKSMSTVIRNPNGGFRMYSKGASEIILRKCNRILDRKGEAVPFKNKDRDDMVRTVIEPMACDGLRTICIAYRDFDDTEPSWDNENEILTELTCIAVVGIEDPVRPEVPDAIAKCKQAGITVRMVTGDNINTARAIATKCGILTPGDDFLCLEGKEFNRLIRNEKGEVEQEKLDKIWPKLRVLARSSPTDKHTLVKGIIDSTVGEHRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLKRRPYGRNKPLISRTMMKNILGHAFYQLIVIFILVFAGEKFFDIDSGRKAPLHSPPSQHYTIVFNTFVLMQLFNEINSRKIHGEKNVFSGIYRNIIFCSVVLGTFICQIFIVEFGGKPFSCTSLSLSQWLWCLFIGIGELLWGQFISAIPTRSLKFLKEAGHGTTKEEITKDAEGLDEIDHAEMELRRGQILWFRGLNRIQTQIDVINTFQTGASFKGVLRRQNMGQHLDVKLVPSSSYIKVVKAFHSSLHESIQKPYNQKSIHSFMTHPEFAIEEELPRTPLLDEEEEENPDKASKFGTRVLLLDGEVTPYANTNNNAVDCNQVQLPQSDSSLQSLETSV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416). By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity).
Catalytic Activity:
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2).
Enzyme Regulation:
ENZYME REGULATION: Activated by calcium/calmodulin.
Active Site:
ACT_SITE 465 465 4-aspartylphosphate intermediate.
Gene Ontology Go:
basolateral plasma membrane
caveola
integral component of plasma membrane
intracellular membrane-bounded organelle
membrane
neuron projection
plasma membrane
protein complex
sperm flagellum
sperm principal piece
T-tubule
Z disc
ATP binding
calcium-transporting ATPase activity
calmodulin binding
metal ion binding
nitric-oxide synthase binding
nitric-oxide synthase inhibitor activity
PDZ domain binding
protein phosphatase 2B binding
scaffold protein binding
blood coagulation
calcium ion export
calcium ion import across plasma membrane
calcium ion transmembrane import into cytosol
calcium ion transmembrane transport
cardiac conduction
cellular calcium ion homeostasis
cellular response to epinephrine stimulus
hippocampus development
ion transmembrane transport
negative regulation of adrenergic receptor signaling pathway involved in heart process
negative regulation of arginine catabolic process
negative regulation of calcineurin-NFAT signaling cascade
negative regulation of cardiac muscle hypertrophy in response to stress
negative regulation of citrulline biosynthetic process
negative regulation of nitric oxide biosynthetic process
negative regulation of nitric oxide mediated signal transduction
negative regulation of nitric-oxide synthase activity
negative regulation of peptidyl-cysteine S-nitrosylation
negative regulation of the force of heart contraction
neural retina development
positive regulation of cAMP-dependent protein kinase activity
positive regulation of peptidyl-serine phosphorylation
regulation of cardiac conduction
regulation of cell cycle G1/S phase transition
regulation of sodium ion transmembrane transport
regulation of transcription from RNA polymerase II promoter
response to hydrostatic pressure
sperm motility
spermatogenesis
transmembrane transport
Gene Ontology Biological Process:
blood coagulation
calcium ion export
calcium ion import across plasma membrane
calcium ion transmembrane import into cytosol
calcium ion transmembrane transport
cardiac conduction
cellular calcium ion homeostasis
cellular response to epinephrine stimulus
hippocampus development
ion transmembrane transport
negative regulation of adrenergic receptor signaling pathway involved in heart process
negative regulation of arginine catabolic process
negative regulation of calcineurin-NFAT signaling cascade
negative regulation of cardiac muscle hypertrophy in response to stress
negative regulation of citrulline biosynthetic process
negative regulation of nitric oxide biosynthetic process
negative regulation of nitric oxide mediated signal transduction
negative regulation of nitric-oxide synthase activity
negative regulation of peptidyl-cysteine S-nitrosylation
negative regulation of the force of heart contraction
neural retina development
positive regulation of cAMP-dependent protein kinase activity
positive regulation of peptidyl-serine phosphorylation
regulation of cardiac conduction
regulation of cell cycle G1/S phase transition
regulation of sodium ion transmembrane transport
regulation of transcription from RNA polymerase II promoter
response to hydrostatic pressure
spermatogenesis
sperm motility
transmembrane transport
Gene Ontology Molecular Function:
ATP binding
calcium-transporting ATPase activity
calmodulin binding
metal ion binding
nitric-oxide synthase binding
nitric-oxide synthase inhibitor activity
PDZ domain binding
protein phosphatase 2B binding
scaffold protein binding
Gene Ontology Cellular Component:
basolateral plasma membrane
caveola
integral component of plasma membrane
intracellular membrane-bounded organelle
membrane
neuron projection
plasma membrane
protein complex
sperm flagellum
sperm principal piece
T-tubule
Z disc
Keywords:
3D-structure
ATP-binding
Alternative splicing
Calcium
Calcium transport
Calmodulin-binding
Cell membrane
Cell projection
Complete proteome
Direct protein sequencing
Hydrolase
Ion transport
Magnesium
Membrane
Metal-binding
Nucleotide-binding
Phosphoprotein
Reference proteome
Transmembrane
Transmembrane helix
Transport
Interacts With:
P01258; Q63622; Q62936

Publication

PubMed ID:
2137451 1531651 17974005 16710414 15489334 8700162 2963820 2966397 8245032 8530416 12763866 21269460 22084111 24275569 25944712 10493800