Names & Taxonomy
- Uniprot ID:
- P23528
- Entry Name:
- COF1_HUMAN
- Status:
- reviewed
- Protein Names:
- Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)
- Gene Names:
- CFL1 CFL
- Gene Names Primary:
- CFL1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 166
- Sequence:
- MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDVGQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus matrix
Function
- Function:
- Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation.
- Gene Ontology Go:
- actin cytoskeleton
cytoplasm
extracellular exosome
extracellular space
focal adhesion
lamellipodium membrane
membrane
nuclear matrix
nucleus
ruffle membrane
vesicle
actin cytoskeleton organization
actin filament depolymerization
axon guidance
blood coagulation
cytoskeleton organization
ephrin receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
innate immune response
negative regulation of apoptotic process
platelet activation
platelet degranulation
positive regulation by host of viral process
regulation of cell morphogenesis
regulation of dendritic spine morphogenesis
response to virus
Rho protein signal transduction - Gene Ontology Biological Process:
- actin cytoskeleton organization
actin filament depolymerization
axon guidance
blood coagulation
cytoskeleton organization
ephrin receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
innate immune response
negative regulation of apoptotic process
platelet activation
platelet degranulation
positive regulation by host of viral process
regulation of cell morphogenesis
regulation of dendritic spine morphogenesis
response to virus
Rho protein signal transduction - Gene Ontology Cellular Component:
- actin cytoskeleton
cytoplasm
extracellular exosome
extracellular space
focal adhesion
lamellipodium membrane
membrane
nuclear matrix
nucleus
ruffle membrane
vesicle - Keywords:
- 3D-structure
Acetylation
Actin-binding
Cell membrane
Cell projection
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Membrane
Nucleus
Phosphoprotein
Reference proteome - Interacts With:
- P60709; P63261; P54253; Q549N0; P53667; P03419; Q13393; O14939; Q1KLZ0; Q8WYL5; P63104