Names & Taxonomy
- Uniprot ID:
- P23469
- Entry Name:
- PTPRE_HUMAN
- Status:
- reviewed
- Protein Names:
- Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48)
- Gene Names:
- PTPRE
- Gene Names Primary:
- PTPRE
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 700
- Sequence:
- MEPLCPLLLVGFSLPLARALRGNETTADSNETTTTSGPPDPGASQPLLAWLLLPLLLLLLVLLLAAYFFRFRKQRKAVVSTSDKKMPNGILEEQEQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYANFK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Cytoplasm. Note=Predominantly cytoplasmic. A small fraction is also associated with nucleus and membrane. Insulin induces translocation to the membrane (By similarity).
Function
- Function:
- Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity).
- Catalytic Activity:
- Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
- Active Site:
- ACT_SITE 335 335 Phosphocysteine intermediate.
- Cross Reference Drug Bank:
- DB00630
- Gene Ontology Go:
- cytoplasm
integral component of membrane
nucleus
plasma membrane
transmembrane receptor protein tyrosine phosphatase activity
negative regulation of insulin receptor signaling pathway
protein dephosphorylation
regulation of mast cell activation
transmembrane receptor protein tyrosine phosphatase signaling pathway - Gene Ontology Biological Process:
- negative regulation of insulin receptor signaling pathway
protein dephosphorylation
regulation of mast cell activation
transmembrane receptor protein tyrosine phosphatase signaling pathway - Gene Ontology Molecular Function:
- transmembrane receptor protein tyrosine phosphatase activity
- Gene Ontology Cellular Component:
- cytoplasm
integral component of membrane
nucleus
plasma membrane - Keywords:
- 3D-structure
Alternative initiation
Alternative promoter usage
Cell membrane
Complete proteome
Cytoplasm
Glycoprotein
Hydrolase
Membrane
Phosphoprotein
Protein phosphatase
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix