Names & Taxonomy

Uniprot ID:
P23469
Entry Name:
PTPRE_HUMAN
Status:
reviewed
Protein Names:
Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48)
Gene Names:
PTPRE
Gene Names Primary:
PTPRE
Organism:
Homo sapiens (Human)

Structure

Length:
700
Sequence:
MEPLCPLLLVGFSLPLARALRGNETTADSNETTTTSGPPDPGASQPLLAWLLLPLLLLLLVLLLAAYFFRFRKQRKAVVSTSDKKMPNGILEEQEQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYANFK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Cytoplasm. Note=Predominantly cytoplasmic. A small fraction is also associated with nucleus and membrane. Insulin induces translocation to the membrane (By similarity).

Function

Function:
Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity).
Catalytic Activity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
Active Site:
ACT_SITE 335 335 Phosphocysteine intermediate.
Cross Reference Drug Bank:
DB00630
Gene Ontology Go:
cytoplasm
integral component of membrane
nucleus
plasma membrane
transmembrane receptor protein tyrosine phosphatase activity
negative regulation of insulin receptor signaling pathway
protein dephosphorylation
regulation of mast cell activation
transmembrane receptor protein tyrosine phosphatase signaling pathway
Gene Ontology Biological Process:
negative regulation of insulin receptor signaling pathway
protein dephosphorylation
regulation of mast cell activation
transmembrane receptor protein tyrosine phosphatase signaling pathway
Gene Ontology Molecular Function:
transmembrane receptor protein tyrosine phosphatase activity
Gene Ontology Cellular Component:
cytoplasm
integral component of membrane
nucleus
plasma membrane
Keywords:
3D-structure
Alternative initiation
Alternative promoter usage
Cell membrane
Complete proteome
Cytoplasm
Glycoprotein
Hydrolase
Membrane
Phosphoprotein
Protein phosphatase
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix

Publication

PubMed ID:
2170109 12121439 14702039 15164054 15489334 8618876 8610169 9914474 10980613 19690332 19167335