Names & Taxonomy
- Uniprot ID:
- P23434
- Entry Name:
- GCSH_HUMAN
- Status:
- reviewed
- Protein Names:
- Glycine cleavage system H protein, mitochondrial (Lipoic acid-containing protein)
- Gene Names:
- GCSH
- Gene Names Primary:
- GCSH
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 173
- Sequence:
- MALRVVRSVRALLCTLRAVPSPAAPCPPRPWQLGVGAVRTLRTGPALLSVRKFTEKHEWVTTENGIGTVGISNFAQEALGDVVYCSLPEVGTKLNKQDEFGALESVKAASELYSPLSGEVTEINEALAENPGLVNKSCYEDGWLIKMTLSNPSELDELMSEEAYEKYIKSIEE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion.
Function
- Function:
- The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).
- Cofactor:
- COFACTOR: Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088; ; Note=Binds 1 lipoyl cofactor covalently.;
- Cross Reference Drug Bank:
- DB00145
- Gene Ontology Go:
- glycine cleavage complex
mitochondrial matrix
mitochondrion
aminomethyltransferase activity
cellular nitrogen compound metabolic process
glycine catabolic process
glycine decarboxylation via glycine cleavage system
glyoxylate metabolic process
methylation
small molecule metabolic process - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
glycine catabolic process
glycine decarboxylation via glycine cleavage system
glyoxylate metabolic process
methylation
small molecule metabolic process - Gene Ontology Molecular Function:
- aminomethyltransferase activity
- Gene Ontology Cellular Component:
- glycine cleavage complex
mitochondrial matrix
mitochondrion - Keywords:
- Complete proteome
Lipoyl
Mitochondrion
Polymorphism
Reference proteome
Transit peptide