Names & Taxonomy
- Uniprot ID:
- P23381
- Entry Name:
- SYWC_HUMAN
- Status:
- reviewed
- Protein Names:
- Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Interferon-induced protein 53) (IFP53) (Tryptophanyl-tRNA synthetase) (TrpRS) (hWRS) [Cleaved into: T1-TrpRS; T2-TrpRS]
- Gene Names:
- WARS IFI53 WRS
- Gene Names Primary:
- WARS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 471
- Sequence:
- MPNSEPASLLELFNSIATQGELVRSLKAGNASKDEIDSAVKMLVSLKMSYKAAAGEDYKADCPPGNPAPTSNHGPDATEAEEDFVDPWTVQTSSAKGIDYDKLIVRFGSSKIDKELINRIERATGQRPHHFLRRGIFFSHRDMNQVLDAYENKKPFYLYTGRGPSSEAMHVGHLIPFIFTKWLQDVFNVPLVIQMTDDEKYLWKDLTLDQAYSYAVENAKDIIACGFDINKTFIFSDLDYMGMSSGFYKNVVKIQKHVTFNQVKGIFGFTDSDCIGKISFPAIQAAPSFSNSFPQIFRDRTDIQCLIPCAIDQDPYFRMTRDVAPRIGYPKPALLHSTFFPALQGAQTKMSASDPNSSIFLTDTAKQIKTKVNKHAFSGGRDTIEEHRQFGGNCDVDVSFMYLTFFLEDDDKLEQIRKDYTSGAMLTGELKKALIEVLQPLIAEHQARRKEVTDEIVKEFMTPRKLSFDFQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression.
- Catalytic Activity:
- ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).
- Cross Reference Drug Bank:
- DB00150
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
nucleus
ATP binding
tryptophan-tRNA ligase activity
angiogenesis
gene expression
negative regulation of cell proliferation
regulation of angiogenesis
translation
tRNA aminoacylation for protein translation
tryptophanyl-tRNA aminoacylation - Gene Ontology Biological Process:
- angiogenesis
gene expression
negative regulation of cell proliferation
regulation of angiogenesis
translation
tRNA aminoacylation for protein translation
tryptophanyl-tRNA aminoacylation - Gene Ontology Molecular Function:
- ATP binding
tryptophan-tRNA ligase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
nucleus - Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Aminoacyl-tRNA synthetase
Angiogenesis
Complete proteome
Cytoplasm
Direct protein sequencing
Ligase
Nucleotide-binding
Polymorphism
Protein biosynthesis
Reference proteome - Interacts With:
- P54274