Names & Taxonomy
- Uniprot ID:
- P23280
- Entry Name:
- CAH6_HUMAN
- Status:
- reviewed
- Protein Names:
- Carbonic anhydrase 6 (EC 4.2.1.1) (Carbonate dehydratase VI) (Carbonic anhydrase VI) (CA-VI) (Salivary carbonic anhydrase) (Secreted carbonic anhydrase)
- Gene Names:
- CA6
- Gene Names Primary:
- CA6
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 308
- Sequence:
- MRALVLLLSLFLLGGQAQHVSDWTYSEGALDEAHWPQHYPACGGQRQSPINLQRTKVRYNPSLKGLNMTGYETQAGEFPMVNNGHTVQISLPSTMRMTVADGTVYIAQQMHFHWGGASSEISGSEHTVDGIRHVIEIHIVHYNSKYKSYDIAQDAPDGLAVLAAFVEVKNYPENTYYSNFISHLANIKYPGQRTTLTGLDVQDMLPRNLQHYYTYHGSLTTPPCTENVHWFVLADFVKLSRTQVWKLENSLLDHRNKTIHNDYRRTQPLNHRVVESNFPNQEYTLGSEFQFYLHKIEEILDYLRRALN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Reversible hydration of carbon dioxide. Its role in saliva is unknown.
- Catalytic Activity:
- H(2)CO(3) = CO(2) + H(2)O.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by coumarins, sulfonamide derivatives such as acetazolamide (AZA), saccharin and Foscarnet (phosphonoformate trisodium salt).
- Active Site:
- ACT_SITE 85 85 Proton acceptor.
- Cross Reference Drug Bank:
- DB06795 DB00909
- Gene Ontology Go:
- cytosol
extracellular exosome
extracellular region
extracellular space
carbonate dehydratase activity
zinc ion binding
bicarbonate transport
detection of chemical stimulus involved in sensory perception of bitter taste
one-carbon metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- bicarbonate transport
detection of chemical stimulus involved in sensory perception of bitter taste
one-carbon metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- carbonate dehydratase activity
zinc ion binding - Gene Ontology Cellular Component:
- cytosol
extracellular exosome
extracellular region
extracellular space - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Disulfide bond
Glycoprotein
Lyase
Metal-binding
Polymorphism
Reference proteome
Secreted
Signal
Zinc