Names & Taxonomy
- Uniprot ID:
- P23258
- Entry Name:
- TBG1_HUMAN
- Status:
- reviewed
- Protein Names:
- Tubulin gamma-1 chain (Gamma-1-tubulin) (Gamma-tubulin complex component 1) (GCP-1)
- Gene Names:
- TUBG1 TUBG
- Gene Names Primary:
- TUBG1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 451
- Sequence:
- MPREIITLQLGQCGNQIGFEFWKQLCAEHGISPEGIVEEFATEGTDRKDVFFYQADDEHYIPRAVLLDLEPRVIHSILNSPYAKLYNPENIYLSEHGGGAGNNWASGFSQGEKIHEDIFDIIDREADGSDSLEGFVLCHSIAGGTGSGLGSYLLERLNDRYPKKLVQTYSVFPNQDEMSDVVVQPYNSLLTLKRLTQNADCVVVLDNTALNRIATDRLHIQNPSFSQINQLVSTIMSASTTTLRYPGYMNNDLIGLIASLIPTPRLHFLMTGYTPLTTDQSVASVRKTTVLDVMRRLLQPKNVMVSTGRDRQTNHCYIAILNIIQGEVDPTQVHKSLQRIRERKLANFIPWGPASIQVALSRKSPYLPSAHRVSGLMMANHTSISSLFERTCRQYDKLRKREAFLEQFRKEDMFKDNFDEMDTSREIVQQLIDEYHAATRPDYISWGTQEQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function
- Function:
- Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
- Cross Reference Drug Bank:
- DB00570
- Gene Ontology Go:
- apical part of cell
cell leading edge
centriole
centrosome
ciliary basal body
condensed nuclear chromosome
cytoplasm
cytoplasmic microtubule
cytosol
gamma-tubulin complex
nonmotile primary cilium
pericentriolar material
polar microtubule
recycling endosome
GTP binding
GTPase activity
structural constituent of cytoskeleton
cytoplasmic microtubule organization
G2/M transition of mitotic cell cycle
meiotic spindle organization
microtubule cytoskeleton organization
microtubule nucleation
mitotic cell cycle
organelle organization - Gene Ontology Biological Process:
- cytoplasmic microtubule organization
G2/M transition of mitotic cell cycle
meiotic spindle organization
microtubule cytoskeleton organization
microtubule nucleation
mitotic cell cycle
organelle organization - Gene Ontology Molecular Function:
- GTPase activity
GTP binding
structural constituent of cytoskeleton - Gene Ontology Cellular Component:
- apical part of cell
cell leading edge
centriole
centrosome
ciliary basal body
condensed nuclear chromosome
cytoplasm
cytoplasmic microtubule
cytosol
gamma-tubulin complex
nonmotile primary cilium
pericentriolar material
polar microtubule
recycling endosome - Keywords:
- 3D-structure
Complete proteome
Cytoplasm
Cytoskeleton
Disease mutation
GTP-binding
Microtubule
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome - Interacts With:
- O15169; Q96L34; Q08AG7; Q6NZ67