Names & Taxonomy
- Uniprot ID:
- P23219
- Entry Name:
- PGH1_HUMAN
- Status:
- reviewed
- Protein Names:
- Prostaglandin G/H synthase 1 (EC 1.14.99.1) (Cyclooxygenase-1) (COX-1) (Prostaglandin H2 synthase 1) (PGH synthase 1) (PGHS-1) (PHS 1) (Prostaglandin-endoperoxide synthase 1)
- Gene Names:
- PTGS1 COX1
- Gene Names Primary:
- PTGS1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 599
- Sequence:
- MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRSNLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQELVGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
Function
- Function:
- Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.
- Pathway:
- Lipid metabolism; prostaglandin biosynthesis.
- Catalytic Activity:
- Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O.
- Cofactor:
- COFACTOR: Name=heme b; Xref=ChEBI:CHEBI:60344;
- Active Site:
- ACT_SITE 206 206 Proton acceptor.
- Cross Reference Drug Bank:
- DB00316 DB00945 DB01435 DB01419 DB01014 DB00188 DB00963 DB00796 DB00821 DB01136 DB00672 DB00250 DB00035 DB00829 DB00586 DB00711 DB00861 DB00154 DB01075 DB00470 DB00216 DB00402 DB00749 DB00773 DB00573 DB00712 DB01355 DB00327 DB01050 DB00159 DB01181 DB00619 DB00328 DB01029 DB01221 DB06738 DB01009 DB00465 DB06725 DB01283 DB01397 DB00939 DB00784 DB00814 DB00244 DB00350 DB00471 DB00461 DB00788 DB00731 DB06802 DB04552 DB00540 DB00991 DB00812 DB01132 DB00554 DB00412 DB01398 DB00936 DB01399 DB01015 DB00795 DB00605 DB00870 DB00469 DB00857 DB01041 DB01600 DB00500 DB00214 DB05109 DB08814 DB01401 DB00313 DB00582 DB00549 DB00744 DB00425 DB01198
- Gene Ontology Go:
- cytoplasm
endoplasmic reticulum membrane
extracellular exosome
Golgi apparatus
intracellular membrane-bounded organelle
nuclear envelope
nucleus
photoreceptor outer segment
dioxygenase activity
heme binding
lipid binding
metal ion binding
peroxidase activity
prostaglandin-endoperoxide synthase activity
aging
arachidonic acid metabolic process
cellular oxidant detoxification
cyclooxygenase pathway
inflammatory response
learning
lipid metabolic process
maintenance of blood-brain barrier
memory
negative regulation of epinephrine secretion
negative regulation of norepinephrine secretion
positive regulation of smooth muscle contraction
positive regulation of vasoconstriction
prostaglandin biosynthetic process
regulation of blood pressure
regulation of cell proliferation
response to corticosterone
response to fatty acid
response to organonitrogen compound
response to oxidative stress
sensory perception of pain
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- aging
arachidonic acid metabolic process
cellular oxidant detoxification
cyclooxygenase pathway
inflammatory response
learning
lipid metabolic process
maintenance of blood-brain barrier
memory
negative regulation of epinephrine secretion
negative regulation of norepinephrine secretion
positive regulation of smooth muscle contraction
positive regulation of vasoconstriction
prostaglandin biosynthetic process
regulation of blood pressure
regulation of cell proliferation
response to corticosterone
response to fatty acid
response to organonitrogen compound
response to oxidative stress
sensory perception of pain
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- dioxygenase activity
heme binding
lipid binding
metal ion binding
peroxidase activity
prostaglandin-endoperoxide synthase activity - Gene Ontology Cellular Component:
- cytoplasm
endoplasmic reticulum membrane
extracellular exosome
Golgi apparatus
intracellular membrane-bounded organelle
nuclear envelope
nucleus
photoreceptor outer segment - Keywords:
- Alternative splicing
Complete proteome
Dioxygenase
Disulfide bond
EGF-like domain
Endoplasmic reticulum
Fatty acid biosynthesis
Fatty acid metabolism
Glycoprotein
Heme
Iron
Lipid biosynthesis
Lipid metabolism
Membrane
Metal-binding
Microsome
Oxidoreductase
Peroxidase
Polymorphism
Prostaglandin biosynthesis
Prostaglandin metabolism
Reference proteome
Signal