Names & Taxonomy
- Uniprot ID:
- P22891
- Entry Name:
- PROZ_HUMAN
- Status:
- reviewed
- Protein Names:
- Vitamin K-dependent protein Z
- Gene Names:
- PROZ
- Gene Names Primary:
- PROZ
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 400
- Sequence:
- MAGCVPLLQGLVLVLALHRVEPSVFLPASKANDVLVRWKRAGSYLLEELFEGNLEKECYEEICVYEEAREVFENEVVTDEFWRRYKGGSPCISQPCLHNGSCQDSIWGYTCTCSPGYEGSNCELAKNECHPERTDGCQHFCLPGQESYTCSCAQGYRLGEDHKQCVPHDQCACGVLTSEKRAPDLQDLPWQVKLTNSEGKDFCGGVIIRENFVLTTAKCSLLHRNITVKTYFNRTSQDPLMIKITHVHVHMRYDADAGENDLSLLELEWPIQCPGAGLPVCTPEKDFAEHLLIPRTRGLLSGWARNGTDLGNSLTTRPVTLVEGEECGQVLNVTVTTRTYCERSSVAAMHWMDGSVVTREHRGSWFLTGVLGSQPVGGQAHMVLVTKVSRYSLWFKQIMN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids.
- Cross Reference Drug Bank:
- DB00170
- Gene Ontology Go:
- endoplasmic reticulum lumen
extracellular exosome
Golgi lumen
calcium ion binding
serine-type endopeptidase activity
blood coagulation
cellular protein metabolic process
ER to Golgi vesicle-mediated transport
peptidyl-glutamic acid carboxylation
post-translational protein modification
signal peptide processing - Gene Ontology Biological Process:
- blood coagulation
cellular protein metabolic process
ER to Golgi vesicle-mediated transport
peptidyl-glutamic acid carboxylation
post-translational protein modification
signal peptide processing - Gene Ontology Molecular Function:
- calcium ion binding
serine-type endopeptidase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum lumen
extracellular exosome
Golgi lumen - Keywords:
- 3D-structure
Alternative splicing
Blood coagulation
Calcium
Cleavage on pair of basic residues
Complete proteome
Direct protein sequencing
Disulfide bond
EGF-like domain
Gamma-carboxyglutamic acid
Glycoprotein
Hemostasis
Hydroxylation
Polymorphism
Reference proteome
Repeat
Secreted
Serine protease homolog
Signal