Names & Taxonomy
- Uniprot ID:
- P22732
- Entry Name:
- GTR5_HUMAN
- Status:
- reviewed
- Protein Names:
- Solute carrier family 2, facilitated glucose transporter member 5 (Fructose transporter) (Glucose transporter type 5, small intestine) (GLUT-5)
- Gene Names:
- SLC2A5 GLUT5
- Gene Names Primary:
- SLC2A5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 501
- Sequence:
- MEQQDQSMKEGRLTLVLALATLIAAFGSSFQYGYNVAAVNSPALLMQQFYNETYYGRTGEFMEDFPLTLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSRVATSFELIIISRLLVGICAGVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFGLRNLLANVDGWPILLGLTGVPAALQLLLLPFFPESPRYLLIQKKDEAAAKKALQTLRGWDSVDREVAEIRQEDEAEKAAGFISVLKLFRMRSLRWQLLSIIVLMGGQQLSGVNAIYYYADQIYLSAGVPEEHVQYVTAGTGAVNVVMTFCAVFVVELLGRRLLLLLGFSICLIACCVLTAALALQDTVSWMPYISIVCVISYVIGHALGPSPIPALLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGLGPYSFIVFAVICLLTTIYIFLIVPETKAKTFIEINQIFTKMNKVSEVYPEKEELKELPPVTSEQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Apical cell membrane
Function
- Function:
- Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:8333543). Can mediate the uptake of 2-deoxyglucose, but with low efficiency (PubMed:1695905). Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake (By similarity).
- Enzyme Regulation:
- ENZYME REGULATION: The uptake of 2-deoxyglucose is inhibited by cytochalasin B.
- Gene Ontology Go:
- apical plasma membrane
extracellular exosome
integral component of plasma membrane
plasma membrane
sarcolemma
fructose binding
fructose transmembrane transporter activity
glucose transmembrane transporter activity
carbohydrate metabolic process
cellular response to fructose stimulus
fructose import across plasma membrane
fructose transport
glucose transmembrane transport
glucose transport
hexose transport
regulation of systemic arterial blood pressure mediated by a chemical signal
response to fructose
small molecule metabolic process
transmembrane transport - Gene Ontology Biological Process:
- carbohydrate metabolic process
cellular response to fructose stimulus
fructose import across plasma membrane
fructose transport
glucose transmembrane transport
glucose transport
hexose transport
regulation of systemic arterial blood pressure mediated by a chemical signal
response to fructose
small molecule metabolic process
transmembrane transport - Gene Ontology Molecular Function:
- fructose binding
fructose transmembrane transporter activity
glucose transmembrane transporter activity - Gene Ontology Cellular Component:
- apical plasma membrane
extracellular exosome
integral component of plasma membrane
plasma membrane
sarcolemma - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Cell membrane
Complete proteome
Glycoprotein
Membrane
Reference proteome
Sugar transport
Transmembrane
Transmembrane helix
Transport