Names & Taxonomy
- Uniprot ID:
- P22695
- Entry Name:
- QCR2_HUMAN
- Status:
- reviewed
- Protein Names:
- Cytochrome b-c1 complex subunit 2, mitochondrial (Complex III subunit 2) (Core protein II) (Ubiquinol-cytochrome-c reductase complex core protein 2)
- Gene Names:
- UQCRC2
- Gene Names Primary:
- UQCRC2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 453
- Sequence:
- MKLLTRAGSFSRFYSLKVAPKVKATAAPAGAPPQPQDLEFTKLPNGLVIASLENYSPVSRIGLFIKAGSRYEDFSNLGTTHLLRLTSSLTTKGASSFKITRGIEAVGGKLSVTATRENMAYTVECLRGDVDILMEFLLNVTTAPEFRRWEVADLQPQLKIDKAVAFQNPQTHVIENLHAAAYRNALANPLYCPDYRIGKVTSEELHYFVQNHFTSARMALIGLGVSHPVLKQVAEQFLNMRGGLGLSGAKANYRGGEIREQNGDSLVHAAFVAESAVAGSAEANAFSVLQHVLGAGPHVKRGSNTTSHLHQAVAKATQQPFDVSAFNASYSDSGLFGIYTISQATAAGDVIKAAYNQVKTIAQGNLSNTDVQAAKNKLKAGYLMSVESSECFLEEVGSQALVAGSYMPPSTVLQQIDSVANADIINAAKKFVSGQKSMAASGNLGHTPFVDEL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Function
- Function:
- This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex.
- Gene Ontology Go:
- extracellular exosome
mitochondrial inner membrane
mitochondrial respiratory chain complex III
mitochondrion
myelin sheath
nucleoplasm
metalloendopeptidase activity
zinc ion binding
aerobic respiration
cellular metabolic process
mitochondrial electron transport, ubiquinol to cytochrome c
oxidative phosphorylation
protein processing
respiratory electron transport chain
small molecule metabolic process - Gene Ontology Biological Process:
- aerobic respiration
cellular metabolic process
mitochondrial electron transport, ubiquinol to cytochrome c
oxidative phosphorylation
protein processing
respiratory electron transport chain
small molecule metabolic process - Gene Ontology Molecular Function:
- metalloendopeptidase activity
zinc ion binding - Gene Ontology Cellular Component:
- extracellular exosome
mitochondrial inner membrane
mitochondrial respiratory chain complex III
mitochondrion
myelin sheath
nucleoplasm - Keywords:
- Acetylation
Complete proteome
Direct protein sequencing
Disease mutation
Electron transport
Membrane
Mitochondrion
Mitochondrion inner membrane
Polymorphism
Reference proteome
Respiratory chain
Transit peptide
Transport - Interacts With:
- O00555