Names & Taxonomy
- Uniprot ID:
- P22460
- Entry Name:
- KCNA5_HUMAN
- Status:
- reviewed
- Protein Names:
- Potassium voltage-gated channel subfamily A member 5 (HPCN1) (Voltage-gated potassium channel HK2) (Voltage-gated potassium channel subunit Kv1.5)
- Gene Names:
- KCNA5
- Gene Names Primary:
- KCNA5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 613
- Sequence:
- MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDADSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSLYALCLDTSRETDL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
- Intramembrane:
- INTRAMEM 468 479 Helical; Name=Pore helix.
Function
- Function:
- Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12130714). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed:12130714). Homotetrameric channels display rapid activation and slow inactivation (PubMed:8505626, PubMed:12130714). May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation (PubMed:11524461).
- Cross Reference Drug Bank:
- DB06637
- Gene Ontology Go:
- cytosol
endoplasmic reticulum
Golgi apparatus
integral component of plasma membrane
intercalated disc
intracellular canaliculus
membrane raft
perinuclear region of cytoplasm
plasma membrane
potassium channel complex
voltage-gated potassium channel complex
Z disc
alpha-actinin binding
delayed rectifier potassium channel activity
outward rectifier potassium channel activity
potassium channel inhibitor activity
protein kinase binding
scaffold protein binding
voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization
voltage-gated potassium channel activity involved in SA node cell action potential repolarization
atrial cardiac muscle cell action potential
membrane hyperpolarization
membrane repolarization during bundle of His cell action potential
membrane repolarization during SA node cell action potential
negative regulation of cytosolic calcium ion concentration
negative regulation of potassium ion transport
Notch signaling pathway
positive regulation of G1/S transition of mitotic cell cycle
positive regulation of myoblast proliferation
potassium ion export
potassium ion homeostasis
potassium ion transmembrane transport
potassium ion transport
protein homooligomerization
regulation of atrial cardiac muscle cell membrane repolarization
regulation of heart rate by cardiac conduction
regulation of insulin secretion
regulation of membrane potential
regulation of potassium ion transport
regulation of vasoconstriction
response to hydrogen peroxide
response to hyperoxia
response to hypoxia
response to mechanical stimulus
response to organic substance
synaptic transmission - Gene Ontology Biological Process:
- atrial cardiac muscle cell action potential
membrane hyperpolarization
membrane repolarization during bundle of His cell action potential
membrane repolarization during SA node cell action potential
negative regulation of cytosolic calcium ion concentration
negative regulation of potassium ion transport
Notch signaling pathway
positive regulation of G1/S transition of mitotic cell cycle
positive regulation of myoblast proliferation
potassium ion export
potassium ion homeostasis
potassium ion transmembrane transport
potassium ion transport
protein homooligomerization
regulation of atrial cardiac muscle cell membrane repolarization
regulation of heart rate by cardiac conduction
regulation of insulin secretion
regulation of membrane potential
regulation of potassium ion transport
regulation of vasoconstriction
response to hydrogen peroxide
response to hyperoxia
response to hypoxia
response to mechanical stimulus
response to organic substance
synaptic transmission - Gene Ontology Molecular Function:
- alpha-actinin binding
delayed rectifier potassium channel activity
outward rectifier potassium channel activity
potassium channel inhibitor activity
protein kinase binding
scaffold protein binding
voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization
voltage-gated potassium channel activity involved in SA node cell action potential repolarization - Gene Ontology Cellular Component:
- cytosol
endoplasmic reticulum
Golgi apparatus
integral component of plasma membrane
intercalated disc
intracellular canaliculus
membrane raft
perinuclear region of cytoplasm
plasma membrane
potassium channel complex
voltage-gated potassium channel complex
Z disc - Keywords:
- Alternative splicing
Atrial fibrillation
Cell membrane
Complete proteome
Ion channel
Ion transport
Isopeptide bond
Lipoprotein
Membrane
Palmitate
Phosphoprotein
Polymorphism
Potassium
Potassium channel
Potassium transport
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport
Ubl conjugation
Voltage-gated channel - Interacts With:
- P35609