Names & Taxonomy

Uniprot ID:
P21964
Entry Name:
COMT_HUMAN
Status:
reviewed
Protein Names:
Catechol O-methyltransferase (EC 2.1.1.6)
Gene Names:
COMT
Gene Names Primary:
COMT
Organism:
Homo sapiens (Human)

Structure

Length:
271
Sequence:
MPEAPPLLLAAVLLGLVLLVVLLLLLRHWGWGLCLIGWNEFILQPIHNLLMGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGPGSEAGP
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Isoform Soluble: Cytoplasm.; Isoform Membrane-bound: Cell membrane; Single-pass type II membrane protein; Extracellular side

Function

Function:
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Catalytic Activity:
S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol.
Cofactor:
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; ; Note=Binds 1 Mg(2+) ion per subunit.;
Cross Reference Drug Bank:
DB00286 DB00255 DB00841 DB00988 DB00494 DB00968 DB01141 DB00118 DB01420 DB00323
Gene Ontology Go:
axon
cell body
cytosol
dendritic spine
extracellular exosome
integral component of membrane
membrane
mitochondrion
plasma membrane
postsynaptic membrane
catechol O-methyltransferase activity
magnesium ion binding
O-methyltransferase activity
cellular response to phosphate starvation
developmental process
dopamine catabolic process
estrogen metabolic process
female pregnancy
learning
methylation
multicellular organismal reproductive process
negative regulation of dopamine metabolic process
negative regulation of renal sodium excretion
negative regulation of smooth muscle cell proliferation
neurotransmitter biosynthetic process
neurotransmitter catabolic process
positive regulation of homocysteine metabolic process
regulation of sensory perception of pain
response to drug
response to lipopolysaccharide
response to organic cyclic compound
response to pain
short-term memory
small molecule metabolic process
synaptic transmission
xenobiotic metabolic process
Gene Ontology Biological Process:
cellular response to phosphate starvation
developmental process
dopamine catabolic process
estrogen metabolic process
female pregnancy
learning
methylation
multicellular organismal reproductive process
negative regulation of dopamine metabolic process
negative regulation of renal sodium excretion
negative regulation of smooth muscle cell proliferation
neurotransmitter biosynthetic process
neurotransmitter catabolic process
positive regulation of homocysteine metabolic process
regulation of sensory perception of pain
response to drug
response to lipopolysaccharide
response to organic cyclic compound
response to pain
short-term memory
small molecule metabolic process
synaptic transmission
xenobiotic metabolic process
Gene Ontology Molecular Function:
catechol O-methyltransferase activity
magnesium ion binding
O-methyltransferase activity
Gene Ontology Cellular Component:
axon
cell body
cytosol
dendritic spine
extracellular exosome
integral component of membrane
membrane
mitochondrion
plasma membrane
postsynaptic membrane
Keywords:
3D-structure
Alternative initiation
Catecholamine metabolism
Cell membrane
Complete proteome
Cytoplasm
Direct protein sequencing
Magnesium
Membrane
Metal-binding
Methyltransferase
Neurotransmitter degradation
Phosphoprotein
Polymorphism
Reference proteome
S-adenosyl-L-methionine
Signal-anchor
Transferase
Transmembrane
Transmembrane helix
Interacts With:
P30260; Q15323; Q6A162; P26371; Q15645

Publication

PubMed ID:
1707278 1847521 8055944 14702039 15461802 10591208 15489334 8020475 1993083 1765063 21269460 21846718 24275569 25944712 18486144 8807664 10395222 10391209 15645182 18474266 18442637