Names & Taxonomy
- Uniprot ID:
- P21912
- Entry Name:
- SDHB_HUMAN
- Status:
- reviewed
- Protein Names:
- Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC 1.3.5.1) (Iron-sulfur subunit of complex II) (Ip)
- Gene Names:
- SDHB SDH SDH1
- Gene Names Primary:
- SDHB
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 280
- Sequence:
- MAAVVALSLRRRLPATTLGGACLQASRGAQTAAATAPRIKKFAIYRWDPDKAGDKPHMQTYEVDLNKCGPMVLDALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTNLNKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSLYRCHTIMNCTRTCPKGLNPGKAIAEIKKMMATYKEKKASV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Function
- Function:
- Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
- Pathway:
- Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.
- Catalytic Activity:
- Succinate + a quinone = fumarate + a quinol.
- Cofactor:
- COFACTOR: Name= cluster; Xref=ChEBI:CHEBI:49601;
- Cross Reference Drug Bank:
- DB00139
- Gene Ontology Go:
- extracellular exosome
mitochondrial inner membrane
mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)
mitochondrion
nucleoplasm
plasma membrane
2 iron, 2 sulfur cluster binding
3 iron, 4 sulfur cluster binding
4 iron, 4 sulfur cluster binding
electron carrier activity
metal ion binding
succinate dehydrogenase (ubiquinone) activity
ubiquinone binding
aerobic respiration
cellular metabolic process
respiratory electron transport chain
small molecule metabolic process
succinate metabolic process
tricarboxylic acid cycle - Gene Ontology Biological Process:
- aerobic respiration
cellular metabolic process
respiratory electron transport chain
small molecule metabolic process
succinate metabolic process
tricarboxylic acid cycle - Gene Ontology Molecular Function:
- 2 iron, 2 sulfur cluster binding
3 iron, 4 sulfur cluster binding
4 iron, 4 sulfur cluster binding
electron carrier activity
metal ion binding
succinate dehydrogenase (ubiquinone) activity
ubiquinone binding - Gene Ontology Cellular Component:
- extracellular exosome
mitochondrial inner membrane
mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)
mitochondrion
nucleoplasm
plasma membrane - Keywords:
- 2Fe-2S
3Fe-4S
4Fe-4S
Acetylation
Complete proteome
Disease mutation
Electron transport
Iron
Iron-sulfur
Membrane
Metal-binding
Mitochondrion
Mitochondrion inner membrane
Oxidoreductase
Polymorphism
Reference proteome
Transit peptide
Transport
Tricarboxylic acid cycle - Interacts With:
- P31040