Names & Taxonomy

Uniprot ID:
P21912
Entry Name:
SDHB_HUMAN
Status:
reviewed
Protein Names:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC 1.3.5.1) (Iron-sulfur subunit of complex II) (Ip)
Gene Names:
SDHB SDH SDH1
Gene Names Primary:
SDHB
Organism:
Homo sapiens (Human)

Structure

Length:
280
Sequence:
MAAVVALSLRRRLPATTLGGACLQASRGAQTAAATAPRIKKFAIYRWDPDKAGDKPHMQTYEVDLNKCGPMVLDALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTNLNKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSLYRCHTIMNCTRTCPKGLNPGKAIAEIKKMMATYKEKKASV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Function

Function:
Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Pathway:
Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.
Catalytic Activity:
Succinate + a quinone = fumarate + a quinol.
Cofactor:
COFACTOR: Name= cluster; Xref=ChEBI:CHEBI:49601;
Cross Reference Drug Bank:
DB00139
Gene Ontology Go:
extracellular exosome
mitochondrial inner membrane
mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)
mitochondrion
nucleoplasm
plasma membrane
2 iron, 2 sulfur cluster binding
3 iron, 4 sulfur cluster binding
4 iron, 4 sulfur cluster binding
electron carrier activity
metal ion binding
succinate dehydrogenase (ubiquinone) activity
ubiquinone binding
aerobic respiration
cellular metabolic process
respiratory electron transport chain
small molecule metabolic process
succinate metabolic process
tricarboxylic acid cycle
Gene Ontology Biological Process:
aerobic respiration
cellular metabolic process
respiratory electron transport chain
small molecule metabolic process
succinate metabolic process
tricarboxylic acid cycle
Gene Ontology Molecular Function:
2 iron, 2 sulfur cluster binding
3 iron, 4 sulfur cluster binding
4 iron, 4 sulfur cluster binding
electron carrier activity
metal ion binding
succinate dehydrogenase (ubiquinone) activity
ubiquinone binding
Gene Ontology Cellular Component:
extracellular exosome
mitochondrial inner membrane
mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)
mitochondrion
nucleoplasm
plasma membrane
Keywords:
2Fe-2S
3Fe-4S
4Fe-4S
Acetylation
Complete proteome
Disease mutation
Electron transport
Iron
Iron-sulfur
Membrane
Metal-binding
Mitochondrion
Mitochondrion inner membrane
Oxidoreductase
Polymorphism
Reference proteome
Transit peptide
Transport
Tricarboxylic acid cycle
Interacts With:
P31040

Publication

PubMed ID:
7622059 14702039 16710414 15489334 16751257 2302193 2494655 21269460 24275569 25944712 11404820 12213855 11897817 12000816 14500403 14974914 12618761 15473885 15328326 14715873 17634472 17804857 18678321