Names & Taxonomy
- Uniprot ID:
- P21549
- Entry Name:
- SPYA_HUMAN
- Status:
- reviewed
- Protein Names:
- Serine--pyruvate aminotransferase (SPT) (EC 2.6.1.51) (Alanine--glyoxylate aminotransferase) (AGT) (EC 2.6.1.44)
- Gene Names:
- AGXT AGT1 SPAT
- Gene Names Primary:
- AGXT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 392
- Sequence:
- MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLRIGLLGCNATRENVDRVTEALRAALQHCPKKKL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Peroxisome
Function
- Catalytic Activity:
- L-serine + pyruvate = 3-hydroxypyruvate + L-alanine.; L-alanine + glyoxylate = pyruvate + glycine.
- Cofactor:
- COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
- Cross Reference Drug Bank:
- DB00145 DB00160 DB00133
- Gene Ontology Go:
- mitochondrial matrix
peroxisomal matrix
peroxisome
alanine-glyoxylate transaminase activity
amino acid binding
protein homodimerization activity
protein self-association
pyridoxal phosphate binding
receptor binding
serine-pyruvate transaminase activity
transaminase activity
cellular nitrogen compound metabolic process
glycine biosynthetic process, by transamination of glyoxylate
glyoxylate catabolic process
glyoxylate metabolic process
L-alanine catabolic process
L-cysteine catabolic process
Notch signaling pathway
oxalic acid secretion
proteasomal protein catabolic process
pyruvate biosynthetic process
response to cAMP
response to glucocorticoid
small molecule metabolic process - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
glycine biosynthetic process, by transamination of glyoxylate
glyoxylate catabolic process
glyoxylate metabolic process
L-alanine catabolic process
L-cysteine catabolic process
Notch signaling pathway
oxalic acid secretion
proteasomal protein catabolic process
pyruvate biosynthetic process
response to cAMP
response to glucocorticoid
small molecule metabolic process - Gene Ontology Molecular Function:
- alanine-glyoxylate transaminase activity
amino acid binding
protein homodimerization activity
protein self-association
pyridoxal phosphate binding
receptor binding
serine-pyruvate transaminase activity
transaminase activity - Gene Ontology Cellular Component:
- mitochondrial matrix
peroxisomal matrix
peroxisome - Keywords:
- 3D-structure
Acetylation
Aminotransferase
Complete proteome
Disease mutation
Mitochondrion
Peroxisome
Phosphoprotein
Polymorphism
Pyridoxal phosphate
Reference proteome
Transferase