Names & Taxonomy
- Uniprot ID:
- P21452
- Entry Name:
- NK2R_HUMAN
- Status:
- reviewed
- Protein Names:
- Substance-K receptor (SKR) (NK-2 receptor) (NK-2R) (Neurokinin A receptor) (Tachykinin receptor 2)
- Gene Names:
- TACR2 NK2R NKNAR TAC2R
- Gene Names Primary:
- TACR2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 398
- Sequence:
- MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILAHRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATKCVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLRHLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMAGDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
substance K receptor activity
tachykinin receptor activity
cell surface receptor signaling pathway
excretion
intestine smooth muscle contraction
muscle contraction
negative regulation of luteinizing hormone secretion
operant conditioning
positive regulation of acetylcholine secretion, neurotransmission
positive regulation of smooth muscle contraction
positive regulation of uterine smooth muscle contraction
positive regulation of vascular permeability
prolactin secretion
response to electrical stimulus
tachykinin receptor signaling pathway - Gene Ontology Biological Process:
- cell surface receptor signaling pathway
excretion
intestine smooth muscle contraction
muscle contraction
negative regulation of luteinizing hormone secretion
operant conditioning
positive regulation of acetylcholine secretion, neurotransmission
positive regulation of smooth muscle contraction
positive regulation of uterine smooth muscle contraction
positive regulation of vascular permeability
prolactin secretion
response to electrical stimulus
tachykinin receptor signaling pathway - Gene Ontology Molecular Function:
- substance K receptor activity
tachykinin receptor activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix - Interacts With:
- P20366