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Names & Taxonomy

Uniprot ID:: P21333
Entry Name:: FLNA_HUMAN
Status:: reviewed
Protein Names:: Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)
Gene Names:: FLNA FLN FLN1
Gene Names Primary:: FLNA
Organism:: Homo sapiens (Human)

Structure

Length:: 2647
Sequence:: MSSSHSRAGQSAAGAAPGGGVDTRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLIALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDEEAKKQTPKQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVTNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAPLRPKLNPKKARAYGPGIEPTGNMVKKRAEFTVETRSAGQGEVLVYVEDPAGHQEEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQGPGLEPSGNIANKTTYFEIFTAGAGTGEVEVVIQDPMGQKGTVEPQLEARGDSTYRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVTVGQACNPSACRAVGRGLQPKGVRVKETADFKVYTKGAGSGELKVTVKGPKGEERVKQKDLGDGVYGFEYYPMVPGTYIVTITWGGQNIGRSPFEVKVGTECGNQKVRAWGPGLEGGVVGKSADFVVEAIGDDVGTLGFSVEGPSQAKIECDDKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIRDAPQDFHPDRVKARGPGLEKTGVAVNKPAEFTVDAKHGGKAPLRVQVQDNEGCPVEALVKDNGNGTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCAEAGQGDVSIGIKCAPGVVGPAEADIDFDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATPTSPIRVKVEPSHDASKVKAEGPGLSRTGVELGKPTHFTVNAKAAGKGKLDVQFSGLTKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGVNVTYGGDPIPKSPFSVAVSPSLDLSKIKVSGLGEKVDVGKDQEFTVKSKGAGGQGKVASKIVGPSGAAVPCKVEPGLGADNSVVRFLPREEGPYEVEVTYDGVPVPGSPFPLEAVAPTKPSKVKAFGPGLQGGSAGSPARFTIDTKGAGTGGLGLTVEGPCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVPCFDASKVKCSGPGLERATAGEVGQFQVDCSSAGSAELTIEICSEAGLPAEVYIQDHGDGTHTITYIPLCPGAYTVTIKYGGQPVPNFPSKLQVEPAVDTSGVQCYGPGIEGQGVFREATTEFSVDARALTQTGGPHVKARVANPSGNLTETYVQDRGDGMYKVEYTPYEEGLHSVDVTYDGSPVPSSPFQVPVTEGCDPSRVRVHGPGIQSGTTNKPNKFTVETRGAGTGGLGLAVEGPSEAKMSCMDNKDGSCSVEYIPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTDASKVKCSGPGLSPGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGPYSISVLYGDEEVPRSPFKVKVLPTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGEGLLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAVPTGDASKCTVTVSIGGHGLGAGIGPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVVENEDGTFDIFYTAPQPGKYVICVRFGGEHVPNSPFQVTALAGDQPSVQPPLRSQQLAPQYTYAQGGQQTWAPERPLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPTITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLTHGVVNKPATFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHVPGSPFTARVTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRRRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKTHEAEIVEGENHTYCIRFVPAEMGTHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGNPAEFVVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKATCAPQHGAPGPGPADASKVVAKGLGLSKAYVGQKSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVVVP
Proteomes:: UP000005640

Subcellular location

Subcellular Location:: Cytoplasm, cell cortex. Cytoplasm, cytoskeleton.

Function

Function:: Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintainance (By similarity).
Gene Ontology Go:: actin cytoskeleton
actin filament
apical dendrite
cortical cytoskeleton
cytoplasm
cytosol
dendritic shaft
extracellular exosome
extracellular region
focal adhesion
membrane
Myb complex
neuronal cell body
nucleolus
nucleus
perinuclear region of cytoplasm
plasma membrane
actin filament binding
Fc-gamma receptor I complex binding
G-protein coupled receptor binding
glycoprotein binding
kinase binding
poly(A) RNA binding
protein homodimerization activity
Rac GTPase binding
Ral GTPase binding
Rho GTPase binding
signal transducer activity
small GTPase binding
transcription factor binding
actin crosslink formation
actin cytoskeleton reorganization
adenylate cyclase-inhibiting dopamine receptor signaling pathway
blood coagulation
cell junction assembly
cilium assembly
cytoplasmic sequestering of protein
establishment of protein localization
mitotic spindle assembly
mRNA transcription from RNA polymerase II promoter
negative regulation of apoptotic process
negative regulation of protein catabolic process
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of transcription from RNA polymerase I promoter
platelet activation
platelet aggregation
platelet degranulation
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of integrin-mediated signaling pathway
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of transcription factor import into nucleus
protein localization to cell surface
protein stabilization
receptor clustering
small GTPase mediated signal transduction
Gene Ontology Biological Process:: actin crosslink formation
actin cytoskeleton reorganization
adenylate cyclase-inhibiting dopamine receptor signaling pathway
blood coagulation
cell junction assembly
cilium assembly
cytoplasmic sequestering of protein
establishment of protein localization
mitotic spindle assembly
mRNA transcription from RNA polymerase II promoter
negative regulation of apoptotic process
negative regulation of protein catabolic process
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of transcription from RNA polymerase I promoter
platelet activation
platelet aggregation
platelet degranulation
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of integrin-mediated signaling pathway
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of transcription factor import into nucleus
protein localization to cell surface
protein stabilization
receptor clustering
small GTPase mediated signal transduction
Gene Ontology Molecular Function:: actin filament binding
Fc-gamma receptor I complex binding
glycoprotein binding
G-protein coupled receptor binding
kinase binding
poly(A) RNA binding
protein homodimerization activity
Rac GTPase binding
Ral GTPase binding
Rho GTPase binding
signal transducer activity
small GTPase binding
transcription factor binding
Gene Ontology Cellular Component:: actin cytoskeleton
actin filament
apical dendrite
cortical cytoskeleton
cytoplasm
cytosol
dendritic shaft
extracellular exosome
extracellular region
focal adhesion
membrane
Myb complex
neuronal cell body
nucleolus
nucleus
perinuclear region of cytoplasm
plasma membrane
Keywords:: 3D-structure
Acetylation
Actin-binding
Alternative splicing
Cilium biogenesis/degradation
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Disease mutation
Isopeptide bond
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Ubl conjugation
Interacts With:: Q9WMX2; Q6UY14-3; Q8N264; O95067; P46108; P07148; Q6ZTI6; O75369; Q12948; P62993; P08238; Q9UBY9; P05556; P07228; P26010; Q53G59; Q8TCE9; O14786; P35372; Q86SQ0; Q04864; P15884

Names & Taxonomy

Structure

Subcellular location

Function

Publication