Names & Taxonomy
- Uniprot ID:
- P20711
- Entry Name:
- DDC_HUMAN
- Status:
- reviewed
- Protein Names:
- Aromatic-L-amino-acid decarboxylase (AADC) (EC 4.1.1.28) (DOPA decarboxylase) (DDC)
- Gene Names:
- DDC AADC
- Gene Names Primary:
- DDC
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 480
- Sequence:
- MNASEFRRRGKEMVDYMANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDVEKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMDWLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIMEKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMVATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFNPHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE
- Proteomes:
- UP000005640
Function
- Function:
- Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
- Pathway:
- Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 2/2.
- Catalytic Activity:
- L-dopa = dopamine + CO(2).; 5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO(2).
- Cofactor:
- COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
- Cross Reference Drug Bank:
- DB00915 DB00190 DB00260 DB06262 DB00875 DB00150 DB01235 DB00968
- Gene Ontology Go:
- axon
cytosol
extracellular exosome
neuronal cell body
synaptic vesicle
amino acid binding
aromatic-L-amino-acid decarboxylase activity
enzyme binding
L-dopa decarboxylase activity
pyridoxal phosphate binding
aminergic neurotransmitter loading into synaptic vesicle
catecholamine biosynthetic process
cellular amino acid metabolic process
cellular nitrogen compound metabolic process
cellular response to alkaloid
cellular response to drug
cellular response to growth factor stimulus
circadian rhythm
dopamine biosynthetic process
indolalkylamine biosynthetic process
isoquinoline alkaloid metabolic process
multicellular organism aging
phytoalexin metabolic process
response to pyrethroid
serotonin biosynthetic process
small molecule metabolic process - Gene Ontology Biological Process:
- aminergic neurotransmitter loading into synaptic vesicle
catecholamine biosynthetic process
cellular amino acid metabolic process
cellular nitrogen compound metabolic process
cellular response to alkaloid
cellular response to drug
cellular response to growth factor stimulus
circadian rhythm
dopamine biosynthetic process
indolalkylamine biosynthetic process
isoquinoline alkaloid metabolic process
multicellular organism aging
phytoalexin metabolic process
response to pyrethroid
serotonin biosynthetic process
small molecule metabolic process - Gene Ontology Molecular Function:
- amino acid binding
aromatic-L-amino-acid decarboxylase activity
enzyme binding
L-dopa decarboxylase activity
pyridoxal phosphate binding - Gene Ontology Cellular Component:
- axon
cytosol
extracellular exosome
neuronal cell body
synaptic vesicle - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Catecholamine biosynthesis
Complete proteome
Decarboxylase
Disease mutation
Lyase
Polymorphism
Pyridoxal phosphate
Reference proteome
Repeat - Interacts With:
- P10275