Names & Taxonomy
- Uniprot ID:
- P20645
- Entry Name:
- MPRD_HUMAN
- Status:
- reviewed
- Protein Names:
- Cation-dependent mannose-6-phosphate receptor (CD Man-6-P receptor) (CD-MPR) (46 kDa mannose 6-phosphate receptor) (MPR 46)
- Gene Names:
- M6PR MPR46 MPRD
- Gene Names Primary:
- M6PR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 277
- Sequence:
- MFPFYSCWRTGLLLLLLAVAVRESWQTEEKTCDLVGEKGKESEKELALVKRLKPLFNKSFESTVGQGSDTYIYIFRVCREAGNHTSGAGLVQINKSNGKETVVGRLNETHIFNGSNWIMLIYKGGDEYDNHCGKEQRRAVVMISCNRHTLADNFNPVSEERGKVQDCFYLFEMDSSLACSPEISHLSVGSILLVTFASLVAVYVVGGFLYQRLVVGAKGMEQFPHLAFWQDLGNLVADGCDFVCRSKPRNVPAAYRGVGDDQLGEESEERDDHLLPM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Lysosome membrane; Single-pass type I membrane protein.
Function
- Function:
- Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
- Cross Reference Drug Bank:
- DB01272
- Gene Ontology Go:
- endosome
integral component of plasma membrane
late endosome
lysosomal membrane
membrane
perinuclear region of cytoplasm
trans-Golgi network
mannose binding
mannose transmembrane transporter activity
transmembrane signaling receptor activity
endosome to lysosome transport
receptor-mediated endocytosis
signal transduction - Gene Ontology Biological Process:
- endosome to lysosome transport
receptor-mediated endocytosis
signal transduction - Gene Ontology Molecular Function:
- mannose binding
mannose transmembrane transporter activity
transmembrane signaling receptor activity - Gene Ontology Cellular Component:
- endosome
integral component of plasma membrane
late endosome
lysosomal membrane
membrane
perinuclear region of cytoplasm
trans-Golgi network - Keywords:
- 3D-structure
Complete proteome
Glycoprotein
Lysosome
Membrane
Phosphoprotein
Receptor
Reference proteome
Signal
Transmembrane
Transmembrane helix
Transport