Names & Taxonomy

Uniprot ID:
P20645
Entry Name:
MPRD_HUMAN
Status:
reviewed
Protein Names:
Cation-dependent mannose-6-phosphate receptor (CD Man-6-P receptor) (CD-MPR) (46 kDa mannose 6-phosphate receptor) (MPR 46)
Gene Names:
M6PR MPR46 MPRD
Gene Names Primary:
M6PR
Organism:
Homo sapiens (Human)

Structure

Length:
277
Sequence:
MFPFYSCWRTGLLLLLLAVAVRESWQTEEKTCDLVGEKGKESEKELALVKRLKPLFNKSFESTVGQGSDTYIYIFRVCREAGNHTSGAGLVQINKSNGKETVVGRLNETHIFNGSNWIMLIYKGGDEYDNHCGKEQRRAVVMISCNRHTLADNFNPVSEERGKVQDCFYLFEMDSSLACSPEISHLSVGSILLVTFASLVAVYVVGGFLYQRLVVGAKGMEQFPHLAFWQDLGNLVADGCDFVCRSKPRNVPAAYRGVGDDQLGEESEERDDHLLPM
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Lysosome membrane; Single-pass type I membrane protein.

Function

Function:
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
Cross Reference Drug Bank:
DB01272
Gene Ontology Go:
endosome
integral component of plasma membrane
late endosome
lysosomal membrane
membrane
perinuclear region of cytoplasm
trans-Golgi network
mannose binding
mannose transmembrane transporter activity
transmembrane signaling receptor activity
endosome to lysosome transport
receptor-mediated endocytosis
signal transduction
Gene Ontology Biological Process:
endosome to lysosome transport
receptor-mediated endocytosis
signal transduction
Gene Ontology Molecular Function:
mannose binding
mannose transmembrane transporter activity
transmembrane signaling receptor activity
Gene Ontology Cellular Component:
endosome
integral component of plasma membrane
late endosome
lysosomal membrane
membrane
perinuclear region of cytoplasm
trans-Golgi network
Keywords:
3D-structure
Complete proteome
Glycoprotein
Lysosome
Membrane
Phosphoprotein
Receptor
Reference proteome
Signal
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
2441386 1849818 14702039 15489334 11387475 11886874 18669648 19159218 21269460 24275569 25944712