Names & Taxonomy
- Uniprot ID:
- P20594
- Entry Name:
- ANPRB_HUMAN
- Status:
- reviewed
- Protein Names:
- Atrial natriuretic peptide receptor 2 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type B) (ANP-B) (ANPR-B) (NPR-B) (Guanylate cyclase B) (GC-B)
- Gene Names:
- NPR2 ANPRB
- Gene Names Primary:
- NPR2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1047
- Sequence:
- MALPSLLLLVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPRVGPAVALAVEALGRALPVDLRFVSSELEGACSEYLAPLSAVDLKLYHDPDLLLGPGCVYPAASVARFASHWRLPLLTAGAVASGFSAKNDHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTREQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWWTGRPIPWVKGAPPSDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQFGNSERYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPAERPDFGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGERKGPPGLL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth.
- Catalytic Activity:
- GTP = 3',5'-cyclic GMP + diphosphate.
- Cross Reference Drug Bank:
- DB01613 DB04899
- Gene Ontology Go:
- guanylate cyclase complex, soluble
integral component of membrane
plasma membrane
ATP binding
GTP binding
guanylate cyclase activity
hormone binding
natriuretic peptide receptor activity
peptide hormone binding
protein kinase activity
receptor activity
transmembrane signaling receptor activity
bone development
cardiac conduction
cell surface receptor signaling pathway
cellular response to granulocyte macrophage colony-stimulating factor stimulus
cGMP biosynthetic process
intracellular signal transduction
negative regulation of meiotic cell cycle
negative regulation of oocyte maturation
ossification
receptor guanylyl cyclase signaling pathway
regulation of blood pressure
regulation of cardiac conduction
signal transduction
single organism reproductive process - Gene Ontology Biological Process:
- bone development
cardiac conduction
cell surface receptor signaling pathway
cellular response to granulocyte macrophage colony-stimulating factor stimulus
cGMP biosynthetic process
intracellular signal transduction
negative regulation of meiotic cell cycle
negative regulation of oocyte maturation
ossification
receptor guanylyl cyclase signaling pathway
regulation of blood pressure
regulation of cardiac conduction
signal transduction
single organism reproductive process - Gene Ontology Molecular Function:
- ATP binding
GTP binding
guanylate cyclase activity
hormone binding
natriuretic peptide receptor activity
peptide hormone binding
protein kinase activity
receptor activity
transmembrane signaling receptor activity - Gene Ontology Cellular Component:
- guanylate cyclase complex, soluble
integral component of membrane
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
Dwarfism
GTP-binding
Glycoprotein
Lyase
Membrane
Nucleotide-binding
Osteogenesis
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Signal
Transmembrane
Transmembrane helix
cGMP biosynthesis