Names & Taxonomy
- Uniprot ID:
- P20231
- Entry Name:
- TRYB2_HUMAN
- Status:
- reviewed
- Protein Names:
- Tryptase beta-2 (Tryptase-2) (EC 3.4.21.59) (Tryptase II)
- Gene Names:
- TPSB2 TPS2
- Gene Names Primary:
- TPSB2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 275
- Sequence:
- MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted. Note=Released from the secretory granules upon mast cell activation.
Function
- Function:
- Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity.
- Catalytic Activity:
- Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin.
- Active Site:
- ACT_SITE 74 74 Charge relay system.; ACT_SITE 121 121 Charge relay system.; ACT_SITE 224 224 Charge relay system.
- Gene Ontology Go:
- extracellular region
serine-type endopeptidase activity
serine-type peptidase activity - Gene Ontology Molecular Function:
- serine-type endopeptidase activity
serine-type peptidase activity - Gene Ontology Cellular Component:
- extracellular region
- Keywords:
- 3D-structure
Complete proteome
Disulfide bond
Glycoprotein
Hydrolase
Phosphoprotein
Polymorphism
Protease
Reference proteome
Secreted
Serine protease
Signal
Zymogen