Names & Taxonomy
- Uniprot ID:
- P20062
- Entry Name:
- TCO2_HUMAN
- Status:
- reviewed
- Protein Names:
- Transcobalamin-2 (TC-2) (Transcobalamin II) (TC II) (TCII)
- Gene Names:
- TCN2 TC2
- Gene Names Primary:
- TCN2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 427
- Sequence:
- MRHLGAFLFLLGVLGALTEMCEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPSIYVGLRLSSLQAGTKEDLYLHSLKLGYQQCLLGSAFSEDDGDCQGKPSMGQLALYLLALRANCEFVRGHKGDRLVSQLKWFLEDEKRAIGHDHKGHPHTSYYQYGLGILALCLHQKRVHDSVVDKLLYAVEPFHQGHHSVDTAAMAGLAFTCLKRSNFNPGRRQRITMAIRTVREEILKAQTPEGHFGNVYSTPLALQFLMTSPMRGAELGTACLKARVALLASLQDGAFQNALMISQLLPVLNHKTYIDLIFPDCLAPRVMLEPAAETIPQTQEIISVTLQVLSLLPPYRQSISVLAGSTVEDVLKKAHELGGFTYETQASLSGPYLTSVMGKAAGEREFWQLLRDPNTPLLQGIADYRPKDGETIELRLVSW
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.
- Cross Reference Drug Bank:
- DB00115 DB00200
- Gene Ontology Go:
- endosome
extracellular exosome
extracellular region
extracellular space
lysosomal lumen
cobalamin binding
metal ion binding
cobalamin metabolic process
cobalamin transport
cobalt ion transport
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Biological Process:
- cobalamin metabolic process
cobalamin transport
cobalt ion transport
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Molecular Function:
- cobalamin binding
metal ion binding - Gene Ontology Cellular Component:
- endosome
extracellular exosome
extracellular region
extracellular space
lysosomal lumen - Keywords:
- 3D-structure
Alternative splicing
Cobalt
Cobalt transport
Complete proteome
Direct protein sequencing
Disulfide bond
Ion transport
Metal-binding
Polymorphism
Reference proteome
Secreted
Signal
Transport