Names & Taxonomy

Uniprot ID:
P20062
Entry Name:
TCO2_HUMAN
Status:
reviewed
Protein Names:
Transcobalamin-2 (TC-2) (Transcobalamin II) (TC II) (TCII)
Gene Names:
TCN2 TC2
Gene Names Primary:
TCN2
Organism:
Homo sapiens (Human)

Structure

Length:
427
Sequence:
MRHLGAFLFLLGVLGALTEMCEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPSIYVGLRLSSLQAGTKEDLYLHSLKLGYQQCLLGSAFSEDDGDCQGKPSMGQLALYLLALRANCEFVRGHKGDRLVSQLKWFLEDEKRAIGHDHKGHPHTSYYQYGLGILALCLHQKRVHDSVVDKLLYAVEPFHQGHHSVDTAAMAGLAFTCLKRSNFNPGRRQRITMAIRTVREEILKAQTPEGHFGNVYSTPLALQFLMTSPMRGAELGTACLKARVALLASLQDGAFQNALMISQLLPVLNHKTYIDLIFPDCLAPRVMLEPAAETIPQTQEIISVTLQVLSLLPPYRQSISVLAGSTVEDVLKKAHELGGFTYETQASLSGPYLTSVMGKAAGEREFWQLLRDPNTPLLQGIADYRPKDGETIELRLVSW
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted.

Function

Function:
Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.
Cross Reference Drug Bank:
DB00115 DB00200
Gene Ontology Go:
endosome
extracellular exosome
extracellular region
extracellular space
lysosomal lumen
cobalamin binding
metal ion binding
cobalamin metabolic process
cobalamin transport
cobalt ion transport
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process
Gene Ontology Biological Process:
cobalamin metabolic process
cobalamin transport
cobalt ion transport
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process
Gene Ontology Molecular Function:
cobalamin binding
metal ion binding
Gene Ontology Cellular Component:
endosome
extracellular exosome
extracellular region
extracellular space
lysosomal lumen
Keywords:
3D-structure
Alternative splicing
Cobalt
Cobalt transport
Complete proteome
Direct protein sequencing
Disulfide bond
Ion transport
Metal-binding
Polymorphism
Reference proteome
Secreted
Signal
Transport

Publication

PubMed ID:
1708393 8439564 7742531 15461802 10591208 15489334 3782074 8443384 16537422 11159542