Names & Taxonomy

Uniprot ID:
P19793
Entry Name:
RXRA_HUMAN
Status:
reviewed
Protein Names:
Retinoic acid receptor RXR-alpha (Nuclear receptor subfamily 2 group B member 1) (Retinoid X receptor alpha)
Gene Names:
RXRA NR2B1
Gene Names Primary:
RXRA
Organism:
Homo sapiens (Human)

Structure

Length:
462
Sequence:
MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Nucleus

Function

Function:
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.
Cross Reference Drug Bank:
DB00459 DB00210 DB00523 DB00307 DB00749
Gene Ontology Go:
axon
nuclear chromatin
nucleoplasm
nucleus
receptor complex
RNA polymerase II transcription factor complex
9-cis retinoic acid receptor activity
chromatin DNA binding
DNA binding
enzyme binding
protein heterodimerization activity
retinoic acid receptor activity
retinoic acid-responsive element binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
sequence-specific DNA binding
steroid hormone receptor activity
transcription coactivator activity
transcription factor activity, sequence-specific DNA binding
vitamin D receptor binding
zinc ion binding
aging
axon regeneration
bile acid and bile salt transport
bile acid metabolic process
camera-type eye development
cardiac muscle cell proliferation
cellular lipid metabolic process
cellular response to insulin stimulus
cholesterol metabolic process
embryo implantation
gene expression
in utero embryonic development
inflammatory response
liver development
maternal placenta development
midgut development
modulation by virus of host morphology or physiology
negative regulation of cell proliferation
negative regulation of transcription from RNA polymerase II promoter
peroxisome proliferator activated receptor signaling pathway
positive regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
positive regulation of translational initiation by iron
protein homotetramerization
regulation of branching involved in prostate gland morphogenesis
regulation of myelination
response to ethanol
response to glucocorticoid
response to retinoic acid
response to selenium ion
response to vitamin A
response to vitamin D
retinoic acid receptor signaling pathway
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
small molecule metabolic process
transcription initiation from RNA polymerase II promoter
ventricular cardiac muscle cell differentiation
ventricular cardiac muscle tissue morphogenesis
vitamin metabolic process
Gene Ontology Biological Process:
aging
axon regeneration
bile acid and bile salt transport
bile acid metabolic process
camera-type eye development
cardiac muscle cell proliferation
cellular lipid metabolic process
cellular response to insulin stimulus
cholesterol metabolic process
embryo implantation
gene expression
inflammatory response
in utero embryonic development
liver development
maternal placenta development
midgut development
modulation by virus of host morphology or physiology
negative regulation of cell proliferation
negative regulation of transcription from RNA polymerase II promoter
peroxisome proliferator activated receptor signaling pathway
positive regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
positive regulation of translational initiation by iron
protein homotetramerization
regulation of branching involved in prostate gland morphogenesis
regulation of myelination
response to ethanol
response to glucocorticoid
response to retinoic acid
response to selenium ion
response to vitamin A
response to vitamin D
retinoic acid receptor signaling pathway
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
small molecule metabolic process
transcription initiation from RNA polymerase II promoter
ventricular cardiac muscle cell differentiation
ventricular cardiac muscle tissue morphogenesis
vitamin metabolic process
Gene Ontology Molecular Function:
9-cis retinoic acid receptor activity
chromatin DNA binding
DNA binding
enzyme binding
protein heterodimerization activity
retinoic acid receptor activity
retinoic acid-responsive element binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
sequence-specific DNA binding
steroid hormone receptor activity
transcription coactivator activity
transcription factor activity, sequence-specific DNA binding
vitamin D receptor binding
zinc ion binding
Gene Ontology Cellular Component:
axon
nuclear chromatin
nucleoplasm
nucleus
receptor complex
RNA polymerase II transcription factor complex
Keywords:
3D-structure
Alternative splicing
Complete proteome
DNA-binding
Host-virus interaction
Isopeptide bond
Metal-binding
Nucleus
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transcription
Transcription regulation
Ubl conjugation
Zinc
Zinc-finger
Interacts With:
Q03463; Q71SY5; Q15788; Q9JLI4; P27986; P10276; P42224

Publication

PubMed ID:
2159111 18619963 14702039 15164053 15489334 1310260 9267036 10567404 10195690 11162439 11259580 11915042 12039952 15047147 14981089 16574651 16912044 17205979 18669648 19786558 20215566 20068231 24275569 7925381 7746322 7760929 9698548 10698945 10835357 10970886 10669605 10882139 11698662 15610733