Names & Taxonomy
- Uniprot ID:
- P19652
- Entry Name:
- A1AG2_HUMAN
- Status:
- reviewed
- Protein Names:
- Alpha-1-acid glycoprotein 2 (AGP 2) (Orosomucoid-2) (OMD 2)
- Gene Names:
- ORM2 AGP2
- Gene Names Primary:
- ORM2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 201
- Sequence:
- MALSWVLTVLSLLPLLEAQIPLCANLVPVPITNATLDRITGKWFYIASAFRNEEYNKSVQEIQATFFYFTPNKTEDTIFLREYQTRQNQCFYNSSYLNVQRENGTVSRYEGGREHVAHLLFLRDTKTLMFGSYLDDEKNWGLSFYADKPETTKEQLGEFYEALDCLCIPRSDVMYTDWKKDKCEPLEKQHEKERKQEEGES
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
- Cross Reference Drug Bank:
- DB00477 DB00497 DB01041
- Gene Ontology Go:
- blood microparticle
extracellular exosome
extracellular space
acute-phase response
regulation of immune system process
transport - Gene Ontology Biological Process:
- acute-phase response
regulation of immune system process
transport - Gene Ontology Cellular Component:
- blood microparticle
extracellular exosome
extracellular space - Keywords:
- 3D-structure
Acute phase
Complete proteome
Disulfide bond
Glycoprotein
Polymorphism
Pyrrolidone carboxylic acid
Reference proteome
Secreted
Signal
Transport