Names & Taxonomy
- Uniprot ID:
- P19429
- Entry Name:
- TNNI3_HUMAN
- Status:
- reviewed
- Protein Names:
- Troponin I, cardiac muscle (Cardiac troponin I)
- Gene Names:
- TNNI3 TNNC1
- Gene Names Primary:
- TNNI3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 210
- Sequence:
- MADGSSDAAREPRPAPAPIRRRSSNYRAYATEPHAKKKSKISASRKLQLKTLLLQIAKQELEREAEERRGEKGRALSTRCQPLELAGLGFAELQDLCRQLHARVDKVDEERYDIEAKVTKNITEIADLTQKIFDLRGKFKRPTLRRVRISADAMMQALLGARAKESLDLRAHLKQVKKEDTEKENREVGDWRKNIDALSGMEGRKKKFES
- Proteomes:
- UP000005640
Function
- Function:
- Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
- Gene Ontology Go:
- cytosol
sarcomere
troponin complex
actin binding
calcium channel inhibitor activity
calcium-dependent protein binding
metal ion binding
protein domain specific binding
protein kinase binding
troponin C binding
troponin T binding
cardiac conduction
cardiac muscle contraction
cellular calcium ion homeostasis
heart contraction
heart development
muscle filament sliding
negative regulation of ATPase activity
regulation of cardiac conduction
regulation of smooth muscle contraction
regulation of systemic arterial blood pressure by ischemic conditions
skeletal muscle contraction
vasculogenesis
ventricular cardiac muscle tissue morphogenesis - Gene Ontology Biological Process:
- cardiac conduction
cardiac muscle contraction
cellular calcium ion homeostasis
heart contraction
heart development
muscle filament sliding
negative regulation of ATPase activity
regulation of cardiac conduction
regulation of smooth muscle contraction
regulation of systemic arterial blood pressure by ischemic conditions
skeletal muscle contraction
vasculogenesis
ventricular cardiac muscle tissue morphogenesis - Gene Ontology Molecular Function:
- actin binding
calcium channel inhibitor activity
calcium-dependent protein binding
metal ion binding
protein domain specific binding
protein kinase binding
troponin C binding
troponin T binding - Gene Ontology Cellular Component:
- cytosol
sarcomere
troponin complex - Keywords:
- 3D-structure
Acetylation
Actin-binding
Calcium
Cardiomyopathy
Complete proteome
Direct protein sequencing
Disease mutation
Metal-binding
Muscle protein
Phosphoprotein
Reference proteome - Interacts With:
- Q5VU43-11; Q9UKA8-1; Q9UKA8-4; Q59H18; Q59H18-2