Names & Taxonomy

Uniprot ID:
P19429
Entry Name:
TNNI3_HUMAN
Status:
reviewed
Protein Names:
Troponin I, cardiac muscle (Cardiac troponin I)
Gene Names:
TNNI3 TNNC1
Gene Names Primary:
TNNI3
Organism:
Homo sapiens (Human)

Structure

Length:
210
Sequence:
MADGSSDAAREPRPAPAPIRRRSSNYRAYATEPHAKKKSKISASRKLQLKTLLLQIAKQELEREAEERRGEKGRALSTRCQPLELAGLGFAELQDLCRQLHARVDKVDEERYDIEAKVTKNITEIADLTQKIFDLRGKFKRPTLRRVRISADAMMQALLGARAKESLDLRAHLKQVKKEDTEKENREVGDWRKNIDALSGMEGRKKKFES
Proteomes:
UP000005640

Function

Function:
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Gene Ontology Go:
cytosol
sarcomere
troponin complex
actin binding
calcium channel inhibitor activity
calcium-dependent protein binding
metal ion binding
protein domain specific binding
protein kinase binding
troponin C binding
troponin T binding
cardiac conduction
cardiac muscle contraction
cellular calcium ion homeostasis
heart contraction
heart development
muscle filament sliding
negative regulation of ATPase activity
regulation of cardiac conduction
regulation of smooth muscle contraction
regulation of systemic arterial blood pressure by ischemic conditions
skeletal muscle contraction
vasculogenesis
ventricular cardiac muscle tissue morphogenesis
Gene Ontology Biological Process:
cardiac conduction
cardiac muscle contraction
cellular calcium ion homeostasis
heart contraction
heart development
muscle filament sliding
negative regulation of ATPase activity
regulation of cardiac conduction
regulation of smooth muscle contraction
regulation of systemic arterial blood pressure by ischemic conditions
skeletal muscle contraction
vasculogenesis
ventricular cardiac muscle tissue morphogenesis
Gene Ontology Molecular Function:
actin binding
calcium channel inhibitor activity
calcium-dependent protein binding
metal ion binding
protein domain specific binding
protein kinase binding
troponin C binding
troponin T binding
Gene Ontology Cellular Component:
cytosol
sarcomere
troponin complex
Keywords:
3D-structure
Acetylation
Actin-binding
Calcium
Cardiomyopathy
Complete proteome
Direct protein sequencing
Disease mutation
Metal-binding
Muscle protein
Phosphoprotein
Reference proteome
Interacts With:
Q5VU43-11; Q9UKA8-1; Q9UKA8-4; Q59H18; Q59H18-2

Publication

PubMed ID:
2226790 8406024 1934363 8661099 2226863 9346285 12242269 15514163 15601779 18986304 22972900 10387074 12060657 9241277 11815426 12531876 12707239 12974739 15070570 16199542 19590045 21846512