Names & Taxonomy
- Uniprot ID:
- P19320
- Entry Name:
- VCAM1_HUMAN
- Status:
- reviewed
- Protein Names:
- Vascular cell adhesion protein 1 (V-CAM 1) (VCAM-1) (INCAM-100) (CD antigen CD106)
- Gene Names:
- VCAM1 L1CAM
- Gene Names Primary:
- VCAM1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 739
- Sequence:
- MPGKMVVILGASNILWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLVLYFASSLIIPAIGMIIYFARKANMKGSYSLVEAQKSKV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
- Cross Reference Drug Bank:
- DB01136 DB00898
- Gene Ontology Go:
- alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex
apical part of cell
cell surface
early endosome
endoplasmic reticulum
external side of plasma membrane
extracellular exosome
extracellular space
filopodium
Golgi apparatus
integral component of membrane
microvillus
plasma membrane
podosome
sarcolemma
cell adhesion molecule binding
integrin binding
primary amine oxidase activity
acute inflammatory response
aging
amine metabolic process
B cell differentiation
calcium-mediated signaling using intracellular calcium source
cell adhesion
cell chemotaxis
cell-matrix adhesion
cellular response to tumor necrosis factor
cellular response to vascular endothelial growth factor stimulus
chronic inflammatory response
cytokine-mediated signaling pathway
extracellular matrix organization
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
interferon-gamma-mediated signaling pathway
leukocyte cell-cell adhesion
leukocyte tethering or rolling
membrane to membrane docking
oxidation-reduction process
positive regulation of T cell proliferation
regulation of immune response
response to ethanol
response to hypoxia
response to ionizing radiation
response to lipopolysaccharide
response to nicotine
response to nutrient
response to zinc ion
viral process - Gene Ontology Biological Process:
- acute inflammatory response
aging
amine metabolic process
B cell differentiation
calcium-mediated signaling using intracellular calcium source
cell adhesion
cell chemotaxis
cell-matrix adhesion
cellular response to tumor necrosis factor
cellular response to vascular endothelial growth factor stimulus
chronic inflammatory response
cytokine-mediated signaling pathway
extracellular matrix organization
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
interferon-gamma-mediated signaling pathway
leukocyte cell-cell adhesion
leukocyte tethering or rolling
membrane to membrane docking
oxidation-reduction process
positive regulation of T cell proliferation
regulation of immune response
response to ethanol
response to hypoxia
response to ionizing radiation
response to lipopolysaccharide
response to nicotine
response to nutrient
response to zinc ion
viral process - Gene Ontology Molecular Function:
- cell adhesion molecule binding
integrin binding
primary amine oxidase activity - Gene Ontology Cellular Component:
- alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex
apical part of cell
cell surface
early endosome
endoplasmic reticulum
external side of plasma membrane
extracellular exosome
extracellular space
filopodium
Golgi apparatus
integral component of membrane
microvillus
plasma membrane
podosome
sarcolemma - Keywords:
- 3D-structure
Alternative splicing
Cell adhesion
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Host-virus interaction
Immunoglobulin domain
Membrane
Polymorphism
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix