Names & Taxonomy

Uniprot ID:
P19235
Entry Name:
EPOR_HUMAN
Status:
reviewed
Protein Names:
Erythropoietin receptor (EPO-R)
Gene Names:
EPOR
Gene Names Primary:
EPOR
Organism:
Homo sapiens (Human)

Structure

Length:
508
Sequence:
MDHLGASLWPQVGSLCLLLAGAAWAPPPNLPDPKFESKAALLAARGPEELLCFTERLEDLVCFWEEAASAGVGPGNYSFSYQLEDEPWKLCRLHQAPTARGAVRFWCSLPTADTSSFVPLELRVTAASGAPRYHRVIHINEVVLLDAPVGLVARLADESGHVVLRWLPPPETPMTSHIRYEVDVSAGNGAGSVQRVEILEGRTECVLSNLRGRTRYTFAVRARMAEPSFGGFWSAWSEPVSLLTPSDLDPLILTLSLILVVILVLLTVLALLSHRRALKQKIWPGIPSPESEFEGLFTTHKGNFQLWLYQNDGCLWWSPCTPFTEDPPASLEVLSERCWGTMQAVEPGTDDEGPLLEPVGSEHAQDTYLVLDKWLLPRNPPSEDLPGPGGSVDIVAMDEGSEASSCSSALASKPSPEGASAASFEYTILDPSSQLLRPWTLCPELPPTPPHLKYLYLVVSDSGISTDYSSGDSQGAQGGLSDGPYSNPYENSLIPAAEPLPPSYVACS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Single-pass type I membrane protein.; Isoform EPOR-S: Secreted

Function

Function:
Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.; Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling.
Cross Reference Drug Bank:
DB00012 DB00016 DB08923 DB08894
Gene Ontology Go:
cytosol
external side of plasma membrane
extracellular region
integral component of plasma membrane
erythropoietin receptor activity
identical protein binding
brain development
decidualization
erythropoietin-mediated signaling pathway
heart development
negative regulation of hydrogen peroxide-induced cell death
negative regulation of neuron apoptotic process
positive regulation of cell proliferation
positive regulation of cytosolic calcium ion concentration
positive regulation of ERK1 and ERK2 cascade
positive regulation of neuron projection development
signal transduction
Gene Ontology Biological Process:
brain development
decidualization
erythropoietin-mediated signaling pathway
heart development
negative regulation of hydrogen peroxide-induced cell death
negative regulation of neuron apoptotic process
positive regulation of cell proliferation
positive regulation of cytosolic calcium ion concentration
positive regulation of ERK1 and ERK2 cascade
positive regulation of neuron projection development
signal transduction
Gene Ontology Molecular Function:
erythropoietin receptor activity
identical protein binding
Gene Ontology Cellular Component:
cytosol
external side of plasma membrane
extracellular region
integral component of plasma membrane
Keywords:
3D-structure
Alternative splicing
Cell membrane
Complete proteome
Congenital erythrocytosis
Disease mutation
Disulfide bond
Glycoprotein
Isopeptide bond
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Secreted
Signal
Transmembrane
Transmembrane helix
Ubl conjugation
Interacts With:
Itself; Q8WWM7; Q62225; P01588; P16885; P18031; P29350; O14508

Publication

PubMed ID:
2163695 2163696 1668606 1654273 1324524 14702039 15489334 1668607 1664413 1657727 11756159 7534299 8662939 11722595 12027890 12746455 10374881 11784712 8662530 9808045 9774108 10388848 9974392 8506290 8174675 8608241