Names & Taxonomy
- Uniprot ID:
- P19224
- Entry Name:
- UD16_HUMAN
- Status:
- reviewed
- Protein Names:
- UDP-glucuronosyltransferase 1-6 (UDPGT 1-6) (UGT1*6) (UGT1-06) (UGT1.6) (EC 2.4.1.17) (Phenol-metabolizing UDP-glucuronosyltransferase) (UDP-glucuronosyltransferase 1-F) (UGT-1F) (UGT1F) (UDP-glucuronosyltransferase 1A6)
- Gene Names:
- UGT1A6 GNT1 UGT1
- Gene Names Primary:
- UGT1A6
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 532
- Sequence:
- MACLLRSFQRISAGVFFLALWGMVVGDKLLVVPQDGSHWLSMKDIVEVLSDRGHEIVVVVPEVNLLLKESKYYTRKIYPVPYDQEELKNRYQSFGNNHFAERSFLTAPQTEYRNNMIVIGLYFINCQSLLQDRDTLNFFKESKFDALFTDPALPCGVILAEYLGLPSVYLFRGFPCSLEHTFSRSPDPVSYIPRCYTKFSDHMTFSQRVANFLVNLLEPYLFYCLFSKYEELASAVLKRDVDIITLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGGINCKKRKDLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Microsome. Endoplasmic reticulum membrane
Function
- Function:
- UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 3 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity).
- Catalytic Activity:
- UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
- Cross Reference Drug Bank:
- DB00316 DB08826 DB00688 DB01024 DB00818 DB00313
- Gene Ontology Go:
- endoplasmic reticulum
endoplasmic reticulum membrane
extracellular exosome
integral component of membrane
enzyme binding
glucuronosyltransferase activity
protein heterodimerization activity
protein homodimerization activity
cellular glucuronidation
flavonoid biosynthetic process
flavonoid glucuronidation
negative regulation of cellular glucuronidation
negative regulation of fatty acid metabolic process
negative regulation of glucuronosyltransferase activity
small molecule metabolic process
xenobiotic glucuronidation
xenobiotic metabolic process - Gene Ontology Biological Process:
- cellular glucuronidation
flavonoid biosynthetic process
flavonoid glucuronidation
negative regulation of cellular glucuronidation
negative regulation of fatty acid metabolic process
negative regulation of glucuronosyltransferase activity
small molecule metabolic process
xenobiotic glucuronidation
xenobiotic metabolic process - Gene Ontology Molecular Function:
- enzyme binding
glucuronosyltransferase activity
protein heterodimerization activity
protein homodimerization activity - Gene Ontology Cellular Component:
- endoplasmic reticulum
endoplasmic reticulum membrane
extracellular exosome
integral component of membrane - Keywords:
- Alternative splicing
Complete proteome
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Membrane
Microsome
Polymorphism
Reference proteome
Signal
Transferase
Transmembrane
Transmembrane helix