Names & Taxonomy

Uniprot ID:
P19224
Entry Name:
UD16_HUMAN
Status:
reviewed
Protein Names:
UDP-glucuronosyltransferase 1-6 (UDPGT 1-6) (UGT1*6) (UGT1-06) (UGT1.6) (EC 2.4.1.17) (Phenol-metabolizing UDP-glucuronosyltransferase) (UDP-glucuronosyltransferase 1-F) (UGT-1F) (UGT1F) (UDP-glucuronosyltransferase 1A6)
Gene Names:
UGT1A6 GNT1 UGT1
Gene Names Primary:
UGT1A6
Organism:
Homo sapiens (Human)

Structure

Length:
532
Sequence:
MACLLRSFQRISAGVFFLALWGMVVGDKLLVVPQDGSHWLSMKDIVEVLSDRGHEIVVVVPEVNLLLKESKYYTRKIYPVPYDQEELKNRYQSFGNNHFAERSFLTAPQTEYRNNMIVIGLYFINCQSLLQDRDTLNFFKESKFDALFTDPALPCGVILAEYLGLPSVYLFRGFPCSLEHTFSRSPDPVSYIPRCYTKFSDHMTFSQRVANFLVNLLEPYLFYCLFSKYEELASAVLKRDVDIITLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGGINCKKRKDLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Microsome. Endoplasmic reticulum membrane

Function

Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 3 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity).
Catalytic Activity:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Cross Reference Drug Bank:
DB00316 DB08826 DB00688 DB01024 DB00818 DB00313
Gene Ontology Go:
endoplasmic reticulum
endoplasmic reticulum membrane
extracellular exosome
integral component of membrane
enzyme binding
glucuronosyltransferase activity
protein heterodimerization activity
protein homodimerization activity
cellular glucuronidation
flavonoid biosynthetic process
flavonoid glucuronidation
negative regulation of cellular glucuronidation
negative regulation of fatty acid metabolic process
negative regulation of glucuronosyltransferase activity
small molecule metabolic process
xenobiotic glucuronidation
xenobiotic metabolic process
Gene Ontology Biological Process:
cellular glucuronidation
flavonoid biosynthetic process
flavonoid glucuronidation
negative regulation of cellular glucuronidation
negative regulation of fatty acid metabolic process
negative regulation of glucuronosyltransferase activity
small molecule metabolic process
xenobiotic glucuronidation
xenobiotic metabolic process
Gene Ontology Molecular Function:
enzyme binding
glucuronosyltransferase activity
protein heterodimerization activity
protein homodimerization activity
Gene Ontology Cellular Component:
endoplasmic reticulum
endoplasmic reticulum membrane
extracellular exosome
integral component of membrane
Keywords:
Alternative splicing
Complete proteome
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Membrane
Microsome
Polymorphism
Reference proteome
Signal
Transferase
Transmembrane
Transmembrane helix

Publication

PubMed ID:
1339448 3141926 11434514 15815621 15489334 9466822 18004212 20610558 24275569 9429234 15284531 19204906