Names & Taxonomy
- Uniprot ID:
- P18850
- Entry Name:
- ATF6A_HUMAN
- Status:
- reviewed
- Protein Names:
- Cyclic AMP-dependent transcription factor ATF-6 alpha (cAMP-dependent transcription factor ATF-6 alpha) (Activating transcription factor 6 alpha) (ATF6-alpha) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 alpha]
- Gene Names:
- ATF6
- Gene Names Primary:
- ATF6
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 670
- Sequence:
- MGEPAGVAGTMESPFSPGLFHRLDEDWDSALFAELGYFTDTDELQLEAANETYENNFDNLDFDLDLMPWESDIWDINNQICTVKDIKAEPQPLSPASSSYSVSSPRSVDSYSSTQHVPEELDLSSSSQMSPLSLYGENSNSLSSAEPLKEDKPVTGPRNKTENGLTPKKKIQVNSKPSIQPKPLLLPAAPKTQTNSSVPAKTIIIQTVPTLMPLAKQQPIISLQPAPTKGQTVLLSQPTVVQLQAPGVLPSAQPVLAVAGGVTQLPNHVVNVVPAPSANSPVNGKLSVTKPVLQSTMRNVGSDIAVLRRQQRMIKNRESACQSRKKKKEYMLGLEARLKAALSENEQLKKENGTLKRQLDEVVSENQRLKVPSPKRRVVCVMIVLAFIILNYGPMSMLEQDSRRMNPSVSPANQRRHLLGFSAKEAQDTSDGIIQKNSYRYDHSVSNDKALMVLTEEPLLYIPPPPCQPLINTTESLRLNHELRGWVHRHEVERTKSRRMTNNQQKTRILQGALEQGSNSQLMAVQYTETTSSISRNSGSELQVYYASPRSYQDFFEAIRRRGDTFYVVSFRRDHLLLPATTHNKTTRPKMSIVLPAININENVINGQDYEVMMQIDCQVMDTRILHIKSSSVPPYLRDQQRNQTNTFFGSPPAATEATHVVSTIPESLQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane; Single-pass type II membrane protein.; Processed cyclic AMP-dependent transcription factor ATF-6 alpha: Nucleus. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. THBS4 promotes its nuclear shuttling.
Function
- Function:
- Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.
- Cross Reference Drug Bank:
- DB00852
- Gene Ontology Go:
- endoplasmic reticulum
endoplasmic reticulum membrane
Golgi apparatus
Golgi membrane
integral component of endoplasmic reticulum membrane
membrane
nuclear envelope
nucleoplasm
nucleus
cAMP response element binding
identical protein binding
protein heterodimerization activity
RNA polymerase II regulatory region sequence-specific DNA binding
transcription coactivator activity
transcription factor activity, sequence-specific DNA binding
transcription regulatory region sequence-specific DNA binding
ATF6-mediated unfolded protein response
cellular protein metabolic process
endoplasmic reticulum unfolded protein response
eye development
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
protein folding
regulation of transcription from RNA polymerase II promoter
response to stress
signal transduction
transcription, DNA-templated
visual perception - Gene Ontology Biological Process:
- ATF6-mediated unfolded protein response
cellular protein metabolic process
endoplasmic reticulum unfolded protein response
eye development
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
protein folding
regulation of transcription from RNA polymerase II promoter
response to stress
signal transduction
transcription, DNA-templated
visual perception - Gene Ontology Molecular Function:
- cAMP response element binding
identical protein binding
protein heterodimerization activity
RNA polymerase II regulatory region sequence-specific DNA binding
transcription coactivator activity
transcription factor activity, sequence-specific DNA binding
transcription regulatory region sequence-specific DNA binding - Gene Ontology Cellular Component:
- endoplasmic reticulum
endoplasmic reticulum membrane
Golgi apparatus
Golgi membrane
integral component of endoplasmic reticulum membrane
membrane
nuclear envelope
nucleoplasm
nucleus - Keywords:
- Activator
Complete proteome
DNA-binding
Disease mutation
Endoplasmic reticulum
Glycoprotein
Membrane
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Signal-anchor
Transcription
Transcription regulation
Transmembrane
Transmembrane helix
Unfolded protein response - Interacts With:
- Itself; Q68CJ9; P17861