Names & Taxonomy

Uniprot ID:
P18848
Entry Name:
ATF4_HUMAN
Status:
reviewed
Protein Names:
Cyclic AMP-dependent transcription factor ATF-4 (cAMP-dependent transcription factor ATF-4) (Activating transcription factor 4) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (DNA-binding protein TAXREB67) (Tax-responsive enhancer element-binding protein 67) (TaxREB67)
Gene Names:
ATF4 CREB2 TXREB
Gene Names Primary:
ATF4
Organism:
Homo sapiens (Human)

Structure

Length:
351
Sequence:
MTEMSFLSSEVLVGDLMSPFDQSGLGAEESLGLLDDYLEVAKHFKPHGFSSDKAKAGSSEWLAVDGLVSPSNNSKEDAFSGTDWMLEKMDLKEFDLDALLGIDDLETMPDDLLTTLDDTCDLFAPLVQETNKQPPQTVNPIGHLPESLTKPDQVAPFTFLQPLPLSPGVLSSTPDHSFSLELGSEVDITEGDRKPDYTAYVAMIPQCIKEEDTPSDNDSGICMSPESYLGSPQHSPSTRGSPNRSLPSPGVLCGSARPKPYDPPGEKMVAAKVKGEKLDKKLKKMEQNKTAATRYRQKKRAEQEALTGECKELEKKNEALKERADSLAKEIQYLKDLIEEVRKARGKKRVP
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm

Function

Function:
Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to endoplasmic reticulum (ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors (PubMed:26086088).
Cross Reference Drug Bank:
DB00852
Gene Ontology Go:
ATF1-ATF4 transcription factor complex
ATF4-CREB1 transcription factor complex
CHOP-ATF4 complex
cytoplasm
dendrite membrane
Lewy body core
microtubule organizing center
neuron projection
nuclear periphery
nucleoplasm
nucleus
core promoter sequence-specific DNA binding
DNA binding
leucine zipper domain binding
protein heterodimerization activity
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor binding
sequence-specific DNA binding
transcription factor activity, RNA polymerase II transcription factor binding
transcription factor activity, sequence-specific DNA binding
transcription regulatory region DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
cellular amino acid metabolic process
cellular protein metabolic process
cellular response to amino acid starvation
cellular response to glucose starvation
cellular response to UV
circadian regulation of gene expression
endoplasmic reticulum unfolded protein response
gamma-aminobutyric acid signaling pathway
gluconeogenesis
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
mRNA transcription from RNA polymerase II promoter
negative regulation of oxidative stress-induced neuron death
negative regulation of potassium ion transport
negative regulation of translational initiation in response to stress
PERK-mediated unfolded protein response
positive regulation of apoptotic process
positive regulation of gene expression
positive regulation of neuron apoptotic process
positive regulation of transcription from RNA polymerase I promoter
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
positive regulation of transcription from RNA polymerase II promoter in response to stress
positive regulation of transcription, DNA-templated
positive regulation of vascular endothelial growth factor production
regulation of transcription, DNA-templated
response to endoplasmic reticulum stress
response to manganese-induced endoplasmic reticulum stress
transcription from RNA polymerase II promoter
Gene Ontology Biological Process:
cellular amino acid metabolic process
cellular protein metabolic process
cellular response to amino acid starvation
cellular response to glucose starvation
cellular response to UV
circadian regulation of gene expression
endoplasmic reticulum unfolded protein response
gamma-aminobutyric acid signaling pathway
gluconeogenesis
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
mRNA transcription from RNA polymerase II promoter
negative regulation of oxidative stress-induced neuron death
negative regulation of potassium ion transport
negative regulation of translational initiation in response to stress
PERK-mediated unfolded protein response
positive regulation of apoptotic process
positive regulation of gene expression
positive regulation of neuron apoptotic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
positive regulation of transcription from RNA polymerase II promoter in response to stress
positive regulation of transcription from RNA polymerase I promoter
positive regulation of vascular endothelial growth factor production
regulation of transcription, DNA-templated
response to endoplasmic reticulum stress
response to manganese-induced endoplasmic reticulum stress
transcription from RNA polymerase II promoter
Gene Ontology Molecular Function:
core promoter sequence-specific DNA binding
DNA binding
leucine zipper domain binding
protein heterodimerization activity
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor binding
sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, RNA polymerase II transcription factor binding
transcription factor activity, sequence-specific DNA binding
transcription regulatory region DNA binding
Gene Ontology Cellular Component:
ATF1-ATF4 transcription factor complex
ATF4-CREB1 transcription factor complex
CHOP-ATF4 complex
cytoplasm
dendrite membrane
Lewy body core
microtubule organizing center
neuron projection
nuclear periphery
nucleoplasm
nucleus
Keywords:
3D-structure
Activator
Biological rhythms
Cell membrane
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
DNA-binding
Isopeptide bond
Lipoprotein
Membrane
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Transcription
Transcription regulation
Ubl conjugation
Interacts With:
P18847; Q9Y297; Q9Y297-2; Q9BWC9; P49715; P17676; P49716; P53567; Q9NS37; Q9UIK4-2; O54784; P35638; Q9NRI5; P01100; Q96CN9; Q92805; Q0D2H9; Q08AF8; Q13227; P05412; O95751; O14777; P19387; Q96RU7

Publication

PubMed ID:
1847461 1534408 10591208 15489334 2516827 15775988 15911876 16682973 18940792 20873783 20068231 21408167 22974638 25218447 26086088 11018027