Names & Taxonomy

Uniprot ID:
P18825
Entry Name:
ADA2C_HUMAN
Status:
reviewed
Protein Names:
Alpha-2C adrenergic receptor (Alpha-2 adrenergic receptor subtype C4) (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2CAR)
Gene Names:
ADRA2C ADRA2L2 ADRA2RL2
Gene Names Primary:
ADRA2C
Organism:
Homo sapiens (Human)

Structure

Length:
462
Sequence:
MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Function

Function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
Cross Reference Drug Bank:
DB00543 DB00182 DB00714 DB01238 DB06216 DB00217 DB09128 DB00484 DB01200 DB00248 DB01136 DB00477 DB00575 DB00363 DB01151 DB01142 DB04855 DB06262 DB01363 DB00668 DB01049 DB00800 DB04946 DB00589 DB00408 DB08815 DB00934 DB01365 DB01577 DB01403 DB06148 DB00370 DB00368 DB00540 DB00334 DB00935 DB01267 DB01186 DB00925 DB00413 DB01224 DB00734 DB00268 DB00697 DB00797 DB06694 DB01392 DB00246
Gene Ontology Go:
axon terminus
cytoplasm
endosome
integral component of plasma membrane
plasma membrane
alpha-2A adrenergic receptor binding
alpha2-adrenergic receptor activity
epinephrine binding
protein heterodimerization activity
protein homodimerization activity
activation of MAPK activity by adrenergic receptor signaling pathway
activation of protein kinase B activity
adenylate cyclase-activating adrenergic receptor signaling pathway
blood coagulation
cell-cell signaling
energy reserve metabolic process
epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
female pregnancy
G-protein coupled receptor signaling pathway
negative regulation of epinephrine secretion
negative regulation of norepinephrine secretion
negative regulation of uterine smooth muscle contraction
platelet activation
positive regulation of neuron differentiation
positive regulation of vasoconstriction
regulation of insulin secretion
regulation of sensory perception of pain
small molecule metabolic process
Gene Ontology Biological Process:
activation of MAPK activity by adrenergic receptor signaling pathway
activation of protein kinase B activity
adenylate cyclase-activating adrenergic receptor signaling pathway
blood coagulation
cell-cell signaling
energy reserve metabolic process
epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
female pregnancy
G-protein coupled receptor signaling pathway
negative regulation of epinephrine secretion
negative regulation of norepinephrine secretion
negative regulation of uterine smooth muscle contraction
platelet activation
positive regulation of neuron differentiation
positive regulation of vasoconstriction
regulation of insulin secretion
regulation of sensory perception of pain
small molecule metabolic process
Gene Ontology Molecular Function:
alpha-2A adrenergic receptor binding
alpha2-adrenergic receptor activity
epinephrine binding
protein heterodimerization activity
protein homodimerization activity
Gene Ontology Cellular Component:
axon terminus
cytoplasm
endosome
integral component of plasma membrane
plasma membrane
Keywords:
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix

Publication

PubMed ID:
2842764 9371698 10801795 15319474 1849485