Names & Taxonomy
- Uniprot ID:
- P18545
- Entry Name:
- CNRG_HUMAN
- Status:
- reviewed
- Protein Names:
- Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (GMP-PDE gamma) (EC 3.1.4.35)
- Gene Names:
- PDE6G PDEG
- Gene Names Primary:
- PDE6G
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 87
- Sequence:
- MNLEPPKAEFRSATRVAGGPVTPRKGPPKFKQRQTRQFKSKPPKKGVQGFGDDIPGMEGLGTDITVICPWEAFNHLELHELAQYGII
- Proteomes:
- UP000005640
Function
- Function:
- Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.
- Catalytic Activity:
- Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.
- Cross Reference Drug Bank:
- DB00203 DB00862
- Gene Ontology Go:
- photoreceptor disc membrane
plasma membrane
3',5'-cyclic-GMP phosphodiesterase activity
cGMP binding
enzyme inhibitor activity
activation of MAPK activity
negative regulation of catalytic activity
phototransduction, visible light
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of G-protein coupled receptor protein signaling pathway
regulation of rhodopsin mediated signaling pathway
rhodopsin mediated signaling pathway
visual perception - Gene Ontology Biological Process:
- activation of MAPK activity
negative regulation of catalytic activity
phototransduction, visible light
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of G-protein coupled receptor protein signaling pathway
regulation of rhodopsin mediated signaling pathway
rhodopsin mediated signaling pathway
visual perception - Gene Ontology Molecular Function:
- 3',5'-cyclic-GMP phosphodiesterase activity
cGMP binding
enzyme inhibitor activity - Gene Ontology Cellular Component:
- photoreceptor disc membrane
plasma membrane - Keywords:
- 3D-structure
Acetylation
Complete proteome
Hydrolase
Polymorphism
Reference proteome
Retinitis pigmentosa
Sensory transduction
Vision
cGMP - Interacts With:
- O14503; Q8R511; P62994; Q96JM7; Q9QY17; Q63787