Names & Taxonomy
- Uniprot ID:
- P18283
- Entry Name:
- GPX2_HUMAN
- Status:
- reviewed
- Protein Names:
- Glutathione peroxidase 2 (GPx-2) (GSHPx-2) (EC 1.11.1.9) (Gastrointestinal glutathione peroxidase) (Glutathione peroxidase-gastrointestinal) (GPx-GI) (GSHPx-GI) (Glutathione peroxidase-related protein 2) (GPRP-2)
- Gene Names:
- GPX2
- Gene Names Primary:
- GPX2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 190
- Sequence:
- MAFIAKSFYDLSAISLDGEKVDFNTFRGRAVLIENVASLUGTTTRDFTQLNELQCRFPRRLVVLGFPCNQFGHQENCQNEEILNSLKYVRPGGGYQPTFTLVQKCEVNGQNEHPVFAYLKDKLPYPYDDPFSLMTDPKLIIWSPVRRSDVAWNFEKFLIGPEGEPFRRYSRTFPTINIEPDIKRLLKVAI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Note=Mainly cytoplasmic.
Function
- Function:
- Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.
- Catalytic Activity:
- 2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
- Active Site:
- ACT_SITE 40 40
- Cross Reference Drug Bank:
- DB00143
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
electron carrier activity
glutathione peroxidase activity
cellular oxidant detoxification
gene expression
response to reactive oxygen species
transcription initiation from RNA polymerase II promoter - Gene Ontology Biological Process:
- cellular oxidant detoxification
gene expression
response to reactive oxygen species
transcription initiation from RNA polymerase II promoter - Gene Ontology Molecular Function:
- electron carrier activity
glutathione peroxidase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome - Keywords:
- 3D-structure
Acetylation
Complete proteome
Cytoplasm
Oxidoreductase
Peroxidase
Polymorphism
Reference proteome
Selenocysteine