Names & Taxonomy
- Uniprot ID:
- P17752
- Entry Name:
- TPH1_HUMAN
- Status:
- reviewed
- Protein Names:
- Tryptophan 5-hydroxylase 1 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 1)
- Gene Names:
- TPH1 TPH TPRH TRPH
- Gene Names Primary:
- TPH1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 444
- Sequence:
- MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI
- Proteomes:
- UP000005640
Function
- Pathway:
- Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.
- Catalytic Activity:
- L-tryptophan + tetrahydrobiopterin + O(2) = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.
- Cofactor:
- COFACTOR: Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
- Cross Reference Drug Bank:
- DB00150 DB00360
- Gene Ontology Go:
- cytosol
neuron projection
amino acid binding
iron ion binding
tryptophan 5-monooxygenase activity
aromatic amino acid family metabolic process
bone remodeling
cellular nitrogen compound metabolic process
circadian rhythm
indolalkylamine biosynthetic process
mammary gland alveolus development
negative regulation of ossification
positive regulation of fat cell differentiation
response to immobilization stress
serotonin biosynthetic process
small molecule metabolic process - Gene Ontology Biological Process:
- aromatic amino acid family metabolic process
bone remodeling
cellular nitrogen compound metabolic process
circadian rhythm
indolalkylamine biosynthetic process
mammary gland alveolus development
negative regulation of ossification
positive regulation of fat cell differentiation
response to immobilization stress
serotonin biosynthetic process
small molecule metabolic process - Gene Ontology Molecular Function:
- amino acid binding
iron ion binding
tryptophan 5-monooxygenase activity - Gene Ontology Cellular Component:
- cytosol
neuron projection - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Iron
Metal-binding
Monooxygenase
Oxidoreductase
Phosphoprotein
Reference proteome
Serotonin biosynthesis