Names & Taxonomy

Uniprot ID:
P17752
Entry Name:
TPH1_HUMAN
Status:
reviewed
Protein Names:
Tryptophan 5-hydroxylase 1 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 1)
Gene Names:
TPH1 TPH TPRH TRPH
Gene Names Primary:
TPH1
Organism:
Homo sapiens (Human)

Structure

Length:
444
Sequence:
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI
Proteomes:
UP000005640

Function

Pathway:
Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.
Catalytic Activity:
L-tryptophan + tetrahydrobiopterin + O(2) = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.
Cofactor:
COFACTOR: Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
Cross Reference Drug Bank:
DB00150 DB00360
Gene Ontology Go:
cytosol
neuron projection
amino acid binding
iron ion binding
tryptophan 5-monooxygenase activity
aromatic amino acid family metabolic process
bone remodeling
cellular nitrogen compound metabolic process
circadian rhythm
indolalkylamine biosynthetic process
mammary gland alveolus development
negative regulation of ossification
positive regulation of fat cell differentiation
response to immobilization stress
serotonin biosynthetic process
small molecule metabolic process
Gene Ontology Biological Process:
aromatic amino acid family metabolic process
bone remodeling
cellular nitrogen compound metabolic process
circadian rhythm
indolalkylamine biosynthetic process
mammary gland alveolus development
negative regulation of ossification
positive regulation of fat cell differentiation
response to immobilization stress
serotonin biosynthetic process
small molecule metabolic process
Gene Ontology Molecular Function:
amino acid binding
iron ion binding
tryptophan 5-monooxygenase activity
Gene Ontology Cellular Component:
cytosol
neuron projection
Keywords:
3D-structure
Alternative splicing
Complete proteome
Iron
Metal-binding
Monooxygenase
Oxidoreductase
Phosphoprotein
Reference proteome
Serotonin biosynthesis

Publication

PubMed ID:
2377472 7986090 15489334 9751214 12379098