Names & Taxonomy
- Uniprot ID:
- P17301
- Entry Name:
- ITA2_HUMAN
- Status:
- reviewed
- Protein Names:
- Integrin alpha-2 (CD49 antigen-like family member B) (Collagen receptor) (Platelet membrane glycoprotein Ia) (GPIa) (VLA-2 subunit alpha) (CD antigen CD49b)
- Gene Names:
- ITGA2 CD49B
- Gene Names Primary:
- ITGA2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1181
- Sequence:
- MGPERTGAAPLPLLLVLALSQGILNCCLAYNVGLPEAKIFSGPSSEQFGYAVQQFINPKGNWLLVGSPWSGFPENRMGDVYKCPVDLSTATCEKLNLQTSTSIPNVTEMKTNMSLGLILTRNMGTGGFLTCGPLWAQQCGNQYYTTGVCSDISPDFQLSASFSPATQPCPSLIDVVVVCDESNSIYPWDAVKNFLEKFVQGLDIGPTKTQVGLIQYANNPRVVFNLNTYKTKEEMIVATSQTSQYGGDLTNTFGAIQYARKYAYSAASGGRRSATKVMVVVTDGESHDGSMLKAVIDQCNHDNILRFGIAVLGYLNRNALDTKNLIKEIKAIASIPTERYFFNVSDEAALLEKAGTLGEQIFSIEGTVQGGDNFQMEMSQVGFSADYSSQNDILMLGAVGAFGWSGTIVQKTSHGHLIFPKQAFDQILQDRNHSSYLGYSVAAISTGESTHFVAGAPRANYTGQIVLYSVNENGNITVIQAHRGDQIGSYFGSVLCSVDVDKDTITDVLLVGAPMYMSDLKKEEGRVYLFTIKKGILGQHQFLEGPEGIENTRFGSAIAALSDINMDGFNDVIVGSPLENQNSGAVYIYNGHQGTIRTKYSQKILGSDGAFRSHLQYFGRSLDGYGDLNGDSITDVSIGAFGQVVQLWSQSIADVAIEASFTPEKITLVNKNAQIILKLCFSAKFRPTKQNNQVAIVYNITLDADGFSSRVTSRGLFKENNERCLQKNMVVNQAQSCPEHIIYIQEPSDVVNSLDLRVDISLENPGTSPALEAYSETAKVFSIPFHKDCGEDGLCISDLVLDVRQIPAAQEQPFIVSNQNKRLTFSVTLKNKRESAYNTGIVVDFSENLFFASFSLPVDGTEVTCQVAASQKSVACDVGYPALKREQQVTFTINFDFNLQNLQNQASLSFQALSESQEENKADNLVNLKIPLLYDAEIHLTRSTNINFYEISSDGNVPSIVHSFEDVGPKFIFSLKVTTGSVPVSMATVIIHIPQYTKEKNPLMYLTGVQTDKAGDISCNADINPLKIGQTSSSVSFKSENFRHTKELNCRTASCSNVTCWLKDVHMKGEYFVNVTTRIWNGTFASSTFQTVQLTAAAEINTYNPEIYVIEDNTVTIPLMIMKPDEKAEVPTGVIIGSIIAGILLLLALVAILWKLGFFKRKYEKMTKNPDEIDETTELSS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.; (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for human rotavirus A (PubMed:12941907). Integrin ITGA2:ITGB1 acts as a receptor for human echoviruses 1 and 8 (PubMed:8411387).
- Gene Ontology Go:
- axon terminus
basal part of cell
cell surface
external side of plasma membrane
focal adhesion
integrin alpha2-beta1 complex
integrin complex
nucleus
perinuclear region of cytoplasm
plasma membrane
collagen binding
collagen binding involved in cell-matrix adhesion
collagen receptor activity
metal ion binding
protein complex binding
virus receptor activity
axon guidance
blood coagulation
cell adhesion
cell adhesion mediated by integrin
cell proliferation
cell-matrix adhesion
cell-substrate adhesion
cellular response to estradiol stimulus
cellular response to mechanical stimulus
collagen-activated signaling pathway
detection of mechanical stimulus involved in sensory perception of pain
establishment of protein localization
extracellular matrix organization
female pregnancy
focal adhesion assembly
hepatocyte differentiation
hypotonic response
integrin-mediated signaling pathway
mammary gland development
mesodermal cell differentiation
organ morphogenesis
positive regulation of alkaline phosphatase activity
positive regulation of cell adhesion
positive regulation of cell projection organization
positive regulation of collagen binding
positive regulation of collagen biosynthetic process
positive regulation of DNA binding
positive regulation of epithelial cell migration
positive regulation of inflammatory response
positive regulation of leukocyte migration
positive regulation of phagocytosis, engulfment
positive regulation of positive chemotaxis
positive regulation of smooth muscle cell migration
positive regulation of smooth muscle cell proliferation
positive regulation of smooth muscle contraction
positive regulation of translation
positive regulation of transmission of nerve impulse
response to amine
response to drug
response to hypoxia
response to L-ascorbic acid
response to muscle activity
response to parathyroid hormone
skin morphogenesis
substrate-dependent cell migration - Gene Ontology Biological Process:
- axon guidance
blood coagulation
cell adhesion
cell adhesion mediated by integrin
cell-matrix adhesion
cell proliferation
cell-substrate adhesion
cellular response to estradiol stimulus
cellular response to mechanical stimulus
collagen-activated signaling pathway
detection of mechanical stimulus involved in sensory perception of pain
establishment of protein localization
extracellular matrix organization
female pregnancy
focal adhesion assembly
hepatocyte differentiation
hypotonic response
integrin-mediated signaling pathway
mammary gland development
mesodermal cell differentiation
organ morphogenesis
positive regulation of alkaline phosphatase activity
positive regulation of cell adhesion
positive regulation of cell projection organization
positive regulation of collagen binding
positive regulation of collagen biosynthetic process
positive regulation of DNA binding
positive regulation of epithelial cell migration
positive regulation of inflammatory response
positive regulation of leukocyte migration
positive regulation of phagocytosis, engulfment
positive regulation of positive chemotaxis
positive regulation of smooth muscle cell migration
positive regulation of smooth muscle cell proliferation
positive regulation of smooth muscle contraction
positive regulation of translation
positive regulation of transmission of nerve impulse
response to amine
response to drug
response to hypoxia
response to L-ascorbic acid
response to muscle activity
response to parathyroid hormone
skin morphogenesis
substrate-dependent cell migration - Gene Ontology Molecular Function:
- collagen binding
collagen binding involved in cell-matrix adhesion
collagen receptor activity
metal ion binding
protein complex binding
virus receptor activity - Gene Ontology Cellular Component:
- axon terminus
basal part of cell
cell surface
external side of plasma membrane
focal adhesion
integrin alpha2-beta1 complex
integrin complex
nucleus
perinuclear region of cytoplasm
plasma membrane - Keywords:
- 3D-structure
Calcium
Cell adhesion
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Integrin
Magnesium
Membrane
Metal-binding
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix - Interacts With:
- P05556; P35968; P35282; Q9H0F6