Names & Taxonomy
- Uniprot ID:
- P17181
- Entry Name:
- INAR1_HUMAN
- Status:
- reviewed
- Protein Names:
- Interferon alpha/beta receptor 1 (IFN-R-1) (IFN-alpha/beta receptor 1) (Cytokine receptor class-II member 1) (Cytokine receptor family 2 member 1) (CRF2-1) (Type I interferon receptor 1)
- Gene Names:
- IFNAR1 IFNAR
- Gene Names Primary:
- IFNAR1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 557
- Sequence:
- MMVVLLGATTLVLVAVAPWVLSAAAGGKNLKSPQKVEVDIIDDNFILRWNRSDESVGNVTFSFDYQKTGMDNWIKLSGCQNITSTKCNFSSLKLNVYEEIKLRIRAEKENTSSWYEVDSFTPFRKAQIGPPEVHLEAEDKAIVIHISPGTKDSVMWALDGLSFTYSLVIWKNSSGVEERIENIYSRHKIYKLSPETTYCLKVKAALLTSWKIGVYSPVHCIKTTVENELPPPENIEVSVQNQNYVLKWDYTYANMTFQVQWLHAFLKRNPGNHLYKWKQIPDCENVKTTQCVFPQNVFQKGIYLLRVQASDGNNTSFWSEEIKFDTEIQAFLLPPVFNIRSLSDSFHIYIGAPKQSGNTPVIQDYPLIYEIIFWENTSNAERKIIEKKTDVTVPNLKPLTVYCVKARAHTMDEKLNKSSVFSDAVCEKTKPGNTSKIWLIVGICIALFALPFVIYAAKVFLRCINYVFFPSLKPSSSIDEYFSEQPLKNLLLSTSEEQIEKCFIIENISTIATVEETNQTDEDHKKYSSQTSQDSGNYSNEDESESKTSEELQQDFV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Cell membrane
Function
- Function:
- Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:2153461, PubMed:7665574, PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:21854986). Functions in general as heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:7665574, PubMed:21854986). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).
- Cross Reference Drug Bank:
- DB00011 DB00018 DB00069 DB00060 DB00068 DB05258 DB00008 DB00022
- Gene Ontology Go:
- integral component of plasma membrane
late endosome
lysosome
plasma membrane
type I interferon binding
type I interferon receptor activity
cellular response to interferon-alpha
cytokine-mediated signaling pathway
defense response to virus
JAK-STAT cascade
positive regulation of interferon-beta production
positive regulation of interferon-gamma production
positive regulation of interleukin-1 beta secretion
positive regulation of transcription, DNA-templated
regulation of peptidyl-tyrosine phosphorylation
regulation of type I interferon-mediated signaling pathway
response to lipopolysaccharide
response to virus
T cell activation
type I interferon biosynthetic process
type I interferon signaling pathway - Gene Ontology Biological Process:
- cellular response to interferon-alpha
cytokine-mediated signaling pathway
defense response to virus
JAK-STAT cascade
positive regulation of interferon-beta production
positive regulation of interferon-gamma production
positive regulation of interleukin-1 beta secretion
positive regulation of transcription, DNA-templated
regulation of peptidyl-tyrosine phosphorylation
regulation of type I interferon-mediated signaling pathway
response to lipopolysaccharide
response to virus
T cell activation
type I interferon biosynthetic process
type I interferon signaling pathway - Gene Ontology Molecular Function:
- type I interferon binding
type I interferon receptor activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
late endosome
lysosome
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Endosome
Glycoprotein
Isopeptide bond
Lipoprotein
Lysosome
Membrane
Palmitate
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix
Ubl conjugation - Interacts With:
- Q9UKB1; P42224; P52630