Names & Taxonomy
- Uniprot ID:
- P17050
- Entry Name:
- NAGAB_HUMAN
- Status:
- reviewed
- Protein Names:
- Alpha-N-acetylgalactosaminidase (EC 3.2.1.49) (Alpha-galactosidase B)
- Gene Names:
- NAGA
- Gene Names Primary:
- NAGA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 411
- Sequence:
- MLLKTVLLLGHVAQVLMLDNGLLQTPPMGWLAWERFRCNINCDEDPKNCISEQLFMEMADRMAQDGWRDMGYTYLNIDDCWIGGRDASGRLMPDPKRFPHGIPFLADYVHSLGLKLGIYADMGNFTCMGYPGTTLDKVVQDAQTFAEWKVDMLKLDGCFSTPEERAQGYPKMAAALNATGRPIAFSCSWPAYEGGLPPRVNYSLLADICNLWRNYDDIQDSWWSVLSILNWFVEHQDILQPVAGPGHWNDPDMLLIGNFGLSLEQSRAQMALWTVLAAPLLMSTDLRTISAQNMDILQNPLMIKINQDPLGIQGRRIHKEKSLIEVYMRPLSNKASALVFFSCRTDMPYRYHSSLGQLNFTGSVIYEAQDVYSGDIISGLRDETNFTVIINPSGVVMWYLYPIKNLEMSQQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Lysosome.
Function
- Function:
- Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids.
- Catalytic Activity:
- Cleavage of non-reducing alpha-(1->3)-N-acetylgalactosamine residues from human blood group A and AB mucin glycoproteins, Forssman hapten and blood group A lacto series glycolipids.
- Active Site:
- ACT_SITE 156 156 Nucleophile.; ACT_SITE 217 217 Proton donor.
- Gene Ontology Go:
- cytoplasm
extracellular exosome
lysosome
alpha-galactosidase activity
alpha-N-acetylgalactosaminidase activity
protein homodimerization activity
carbohydrate catabolic process
glycolipid catabolic process
glycoside catabolic process - Gene Ontology Biological Process:
- carbohydrate catabolic process
glycolipid catabolic process
glycoside catabolic process - Gene Ontology Molecular Function:
- alpha-galactosidase activity
alpha-N-acetylgalactosaminidase activity
protein homodimerization activity - Gene Ontology Cellular Component:
- cytoplasm
extracellular exosome
lysosome - Keywords:
- 3D-structure
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Epilepsy
Glycoprotein
Glycosidase
Hydrolase
Lysosome
Phosphoprotein
Reference proteome
Signal