Names & Taxonomy
- Uniprot ID:
- P16662
- Entry Name:
- UD2B7_HUMAN
- Status:
- reviewed
- Protein Names:
- UDP-glucuronosyltransferase 2B7 (UDPGT 2B7) (EC 2.4.1.17) (3,4-catechol estrogen-specific UDPGT) (UDP-glucuronosyltransferase 2B9) (UDPGT 2B9) (UDPGTh-2)
- Gene Names:
- UGT2B7 UGTB2B9
- Gene Names Primary:
- UGT2B7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 529
- Sequence:
- MSVKWTSVILLIQLSFCFSSGNCGKVLVWAAEYSHWMNIKTILDELIQRGHEVTVLASSASILFDPNNSSALKIEIYPTSLTKTELENFIMQQIKRWSDLPKDTFWLYFSQVQEIMSIFGDITRKFCKDVVSNKKFMKKVQESRFDVIFADAIFPCSELLAELFNIPFVYSLSFSPGYTFEKHSGGFIFPPSYVPVVMSELTDQMTFMERVKNMIYVLYFDFWFEIFDMKKWDQFYSEVLGRPTTLSETMGKADVWLIRNSWNFQFPHPLLPNVDFVGGLHCKPAKPLPKEMEDFVQSSGENGVVVFSLGSMVSNMTEERANVIASALAQIPQKVLWRFDGNKPDTLGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFADQPDNIAHMKARGAAVRVDFNTMSSTDLLNALKRVINDPSYKENVMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVCVATVIFIVTKCCLFCFWKFARKAKKGKND
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Microsome membrane
Function
- Function:
- UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
- Catalytic Activity:
- UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
- Cross Reference Drug Bank:
- DB06403 DB01076 DB00564 DB06777 DB00318 DB06695 DB06292 DB00586 DB00445 DB00749 DB00973 DB01544 DB00712 DB01095 DB01050 DB00328 DB00678 DB00227 DB01252 DB00295 DB00688 DB01024 DB00788 DB00842 DB08860 DB06207 DB00641 DB00870 DB06204 DB00313 DB00495
- Gene Ontology Go:
- endoplasmic reticulum membrane
extracellular exosome
integral component of membrane
intracellular membrane-bounded organelle
membrane
glucuronosyltransferase activity
androgen metabolic process
cellular glucuronidation
flavonoid biosynthetic process
flavonoid glucuronidation
lipid metabolic process - Gene Ontology Biological Process:
- androgen metabolic process
cellular glucuronidation
flavonoid biosynthetic process
flavonoid glucuronidation
lipid metabolic process - Gene Ontology Molecular Function:
- glucuronosyltransferase activity
- Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
extracellular exosome
integral component of membrane
intracellular membrane-bounded organelle
membrane - Keywords:
- 3D-structure
Complete proteome
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Lipid metabolism
Membrane
Microsome
Polymorphism
Reference proteome
Signal
Steroid metabolism
Transferase
Transmembrane
Transmembrane helix