Names & Taxonomy

Uniprot ID:
P16662
Entry Name:
UD2B7_HUMAN
Status:
reviewed
Protein Names:
UDP-glucuronosyltransferase 2B7 (UDPGT 2B7) (EC 2.4.1.17) (3,4-catechol estrogen-specific UDPGT) (UDP-glucuronosyltransferase 2B9) (UDPGT 2B9) (UDPGTh-2)
Gene Names:
UGT2B7 UGTB2B9
Gene Names Primary:
UGT2B7
Organism:
Homo sapiens (Human)

Structure

Length:
529
Sequence:
MSVKWTSVILLIQLSFCFSSGNCGKVLVWAAEYSHWMNIKTILDELIQRGHEVTVLASSASILFDPNNSSALKIEIYPTSLTKTELENFIMQQIKRWSDLPKDTFWLYFSQVQEIMSIFGDITRKFCKDVVSNKKFMKKVQESRFDVIFADAIFPCSELLAELFNIPFVYSLSFSPGYTFEKHSGGFIFPPSYVPVVMSELTDQMTFMERVKNMIYVLYFDFWFEIFDMKKWDQFYSEVLGRPTTLSETMGKADVWLIRNSWNFQFPHPLLPNVDFVGGLHCKPAKPLPKEMEDFVQSSGENGVVVFSLGSMVSNMTEERANVIASALAQIPQKVLWRFDGNKPDTLGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFADQPDNIAHMKARGAAVRVDFNTMSSTDLLNALKRVINDPSYKENVMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVCVATVIFIVTKCCLFCFWKFARKAKKGKND
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Microsome membrane

Function

Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
Catalytic Activity:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Cross Reference Drug Bank:
DB06403 DB01076 DB00564 DB06777 DB00318 DB06695 DB06292 DB00586 DB00445 DB00749 DB00973 DB01544 DB00712 DB01095 DB01050 DB00328 DB00678 DB00227 DB01252 DB00295 DB00688 DB01024 DB00788 DB00842 DB08860 DB06207 DB00641 DB00870 DB06204 DB00313 DB00495
Gene Ontology Go:
endoplasmic reticulum membrane
extracellular exosome
integral component of membrane
intracellular membrane-bounded organelle
membrane
glucuronosyltransferase activity
androgen metabolic process
cellular glucuronidation
flavonoid biosynthetic process
flavonoid glucuronidation
lipid metabolic process
Gene Ontology Biological Process:
androgen metabolic process
cellular glucuronidation
flavonoid biosynthetic process
flavonoid glucuronidation
lipid metabolic process
Gene Ontology Molecular Function:
glucuronosyltransferase activity
Gene Ontology Cellular Component:
endoplasmic reticulum membrane
extracellular exosome
integral component of membrane
intracellular membrane-bounded organelle
membrane
Keywords:
3D-structure
Complete proteome
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Lipid metabolism
Membrane
Microsome
Polymorphism
Reference proteome
Signal
Steroid metabolism
Transferase
Transmembrane
Transmembrane helix

Publication

PubMed ID:
2159463 14702039 15815621 15489334 19159218 24275569 17442341 11186130