Names & Taxonomy
- Uniprot ID:
- P16615
- Entry Name:
- AT2A2_HUMAN
- Status:
- reviewed
- Protein Names:
- Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 3.6.3.8) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)
- Gene Names:
- ATP2A2 ATP2B
- Gene Names Primary:
- ATP2A2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1042
- Sequence:
- MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTSGVKQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNVTQWLMVLKISLPVILMDETLKFVARNYLEPGKECVQPATKSCSFSACTDGISWPFVLLIMPLVIWVYSTDTNFSDMFWS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle (PubMed:16402920). Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation (By similarity).
- Catalytic Activity:
- ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2).
- Enzyme Regulation:
- ENZYME REGULATION: Reversibly inhibited by phospholamban (PLN) at low calcium concentrations (By similarity). Inhibited by sarcolipin (SLN) and myoregulin (MRLN) (By similarity). Enhanced by DWORF; DWORF increases activity by displacing sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN) (By similarity).
- Active Site:
- ACT_SITE 351 351 4-aspartylphosphate intermediate.
- Gene Ontology Go:
- calcium ion-transporting ATPase complex
endoplasmic reticulum
endoplasmic reticulum membrane
extrinsic component of cytoplasmic side of plasma membrane
integral component of plasma membrane
longitudinal sarcoplasmic reticulum
membrane
perinuclear region of cytoplasm
platelet dense tubular network membrane
protein complex
ribbon synapse
sarcoplasmic reticulum
sarcoplasmic reticulum membrane
vesicle membrane
ATP binding
calcium ion binding
calcium-transporting ATPase activity
calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential
enzyme binding
protein C-terminus binding
S100 protein binding
blood coagulation
calcium ion import into sarcoplasmic reticulum
calcium ion transmembrane transport
calcium ion transport from cytosol to endoplasmic reticulum
cardiac conduction
cell adhesion
cellular calcium ion homeostasis
cellular response to oxidative stress
endoplasmic reticulum calcium ion homeostasis
epidermis development
ER-nucleus signaling pathway
ion transmembrane transport
negative regulation of heart contraction
organelle organization
positive regulation of endoplasmic reticulum calcium ion concentration
positive regulation of heart rate
regulation of calcium ion-dependent exocytosis of neurotransmitter
regulation of cardiac conduction
regulation of cardiac muscle cell action potential involved in regulation of contraction
regulation of cardiac muscle cell membrane potential
regulation of cardiac muscle contraction by calcium ion signaling
regulation of the force of heart contraction
relaxation of cardiac muscle
response to endoplasmic reticulum stress
response to peptide hormone
sarcoplasmic reticulum calcium ion transport
T-tubule organization
transition between fast and slow fiber
transmembrane transport - Gene Ontology Biological Process:
- blood coagulation
calcium ion import into sarcoplasmic reticulum
calcium ion transmembrane transport
calcium ion transport from cytosol to endoplasmic reticulum
cardiac conduction
cell adhesion
cellular calcium ion homeostasis
cellular response to oxidative stress
endoplasmic reticulum calcium ion homeostasis
epidermis development
ER-nucleus signaling pathway
ion transmembrane transport
negative regulation of heart contraction
organelle organization
positive regulation of endoplasmic reticulum calcium ion concentration
positive regulation of heart rate
regulation of calcium ion-dependent exocytosis of neurotransmitter
regulation of cardiac conduction
regulation of cardiac muscle cell action potential involved in regulation of contraction
regulation of cardiac muscle cell membrane potential
regulation of cardiac muscle contraction by calcium ion signaling
regulation of the force of heart contraction
relaxation of cardiac muscle
response to endoplasmic reticulum stress
response to peptide hormone
sarcoplasmic reticulum calcium ion transport
transition between fast and slow fiber
transmembrane transport
T-tubule organization - Gene Ontology Molecular Function:
- ATP binding
calcium ion binding
calcium-transporting ATPase activity
calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential
enzyme binding
protein C-terminus binding
S100 protein binding - Gene Ontology Cellular Component:
- calcium ion-transporting ATPase complex
endoplasmic reticulum
endoplasmic reticulum membrane
extrinsic component of cytoplasmic side of plasma membrane
integral component of plasma membrane
longitudinal sarcoplasmic reticulum
membrane
perinuclear region of cytoplasm
platelet dense tubular network membrane
protein complex
ribbon synapse
sarcoplasmic reticulum
sarcoplasmic reticulum membrane
vesicle membrane - Keywords:
- ATP-binding
Alternative splicing
Calcium
Calcium transport
Complete proteome
Disease mutation
Endoplasmic reticulum
Epilepsy
Hydrolase
Ion transport
Isopeptide bond
Magnesium
Membrane
Metal-binding
Nitration
Nucleotide-binding
Phosphoprotein
Reference proteome
Sarcoplasmic reticulum
Transmembrane
Transmembrane helix
Transport
Ubl conjugation - Interacts With:
- P41143