Names & Taxonomy

Uniprot ID:
P16581
Entry Name:
LYAM2_HUMAN
Status:
reviewed
Protein Names:
E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E)
Gene Names:
SELE ELAM1
Gene Names Primary:
SELE
Organism:
Homo sapiens (Human)

Structure

Length:
610
Sequence:
MIASQFLSALTLVLLIKESGAWSYNTSTEAMTYDEASAYCQQRYTHLVAIQNKEEIEYLNSILSYSPSYYWIGIRKVNNVWVWVGTQKPLTEEAKNWAPGEPNNRQKDEDCVEIYIKREKDVGMWNDERCSKKKLALCYTAACTNTSCSGHGECVETINNYTCKCDPGFSGLKCEQIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEAPTESNIPLVAGLSAAGLSLLTLAPFLLWLRKCLRKAKKFVPASSCQSLESDGSYQKPSYIL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.
Cross Reference Drug Bank:
DB01136
Gene Ontology Go:
caveola
coated pit
cortical cytoskeleton
extracellular space
integral component of membrane
membrane raft
perinuclear region of cytoplasm
plasma membrane
oligosaccharide binding
phospholipase binding
sialic acid binding
transmembrane signaling receptor activity
actin filament-based process
activation of phospholipase C activity
blood coagulation
calcium-mediated signaling
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
inflammatory response
leukocyte cell-cell adhesion
leukocyte migration
leukocyte migration involved in inflammatory response
leukocyte tethering or rolling
positive regulation of receptor internalization
regulation of inflammatory response
response to interleukin-1
response to lipopolysaccharide
response to tumor necrosis factor
Gene Ontology Biological Process:
actin filament-based process
activation of phospholipase C activity
blood coagulation
calcium-mediated signaling
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
inflammatory response
leukocyte cell-cell adhesion
leukocyte migration
leukocyte migration involved in inflammatory response
leukocyte tethering or rolling
positive regulation of receptor internalization
regulation of inflammatory response
response to interleukin-1
response to lipopolysaccharide
response to tumor necrosis factor
Gene Ontology Molecular Function:
oligosaccharide binding
phospholipase binding
sialic acid binding
transmembrane signaling receptor activity
Gene Ontology Cellular Component:
caveola
coated pit
cortical cytoskeleton
extracellular space
integral component of membrane
membrane raft
perinuclear region of cytoplasm
plasma membrane
Keywords:
3D-structure
Cell adhesion
Cell membrane
Complete proteome
Disulfide bond
EGF-like domain
Glycoprotein
Lectin
Membrane
Polymorphism
Reference proteome
Repeat
Signal
Sushi
Transmembrane
Transmembrane helix

Publication

PubMed ID:
1689848 2466335 1703529 16710414 15489334 1701274 18606703 7681016 7509040 11081633 7533025 8557254 9933738 10391210 10982036 12649084 24688092 25787250