Names & Taxonomy
- Uniprot ID:
- P16473
- Entry Name:
- TSHR_HUMAN
- Status:
- reviewed
- Protein Names:
- Thyrotropin receptor (Thyroid-stimulating hormone receptor) (TSH-R)
- Gene Names:
- TSHR LGR3
- Gene Names Primary:
- TSHR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 764
- Sequence:
- MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLMCNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDYTICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNSTDIQVQKVTHDMRQGLHNMEDVYELIENSHLTPKKQGQISEEYMQTVL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5).
- Cross Reference Drug Bank:
- DB00024
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
receptor complex
G-protein coupled peptide receptor activity
thyroid-stimulating hormone receptor activity
activation of adenylate cyclase activity
adenylate cyclase-activating G-protein coupled receptor signaling pathway
cell-cell signaling
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
hormone-mediated signaling pathway
positive regulation of cell proliferation
thyroid-stimulating hormone signaling pathway - Gene Ontology Biological Process:
- activation of adenylate cyclase activity
adenylate cyclase-activating G-protein coupled receptor signaling pathway
cell-cell signaling
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
hormone-mediated signaling pathway
positive regulation of cell proliferation
thyroid-stimulating hormone signaling pathway - Gene Ontology Molecular Function:
- G-protein coupled peptide receptor activity
thyroid-stimulating hormone receptor activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane
receptor complex - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Congenital hypothyroidism
Direct protein sequencing
Disease mutation
Disulfide bond
G-protein coupled receptor
Glycoprotein
Leucine-rich repeat
Membrane
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transducer
Transmembrane
Transmembrane helix
Publication
- PubMed ID:
- 2558651 2610690 2302212 2293030 1530609 1445355 12508121 15489334 11502179 12045258 15775968 8747461 17542669 11887032 12593721 12930595 10870027 1955520 8413627 7508946 8045989 7989485 7920658 7556878 7800007 7528344 7647578 7488864 8636266 8964822 8954020 9062474 9100579 9253356 9329388 9360555 9398746 9185526 9294132 9349581 9589634 9854118 10199795 10487707 10037070 10560955 11022192 10651846 10720030 10852462 10946859 11095460 11127522 11081252 11128715 11201847 11517004 11549687 11434721 11442002 12213664 12050212 12589819 12788902 14759073 14725684 15163335 15531543 25978107