Names & Taxonomy
- Uniprot ID:
- P16471
- Entry Name:
- PRLR_HUMAN
- Status:
- reviewed
- Protein Names:
- Prolactin receptor (PRL-R)
- Gene Names:
- PRLR
- Gene Names Primary:
- PRLR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 622
- Sequence:
- MKENVASATVFTLLLFLNTCLLNGQLPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTYHREGETLMHECPDYITGGPNSCHFGKQYTSMWRTYIMMVNATNQMGSSFSDELYVDVTYIVQPDPPLELAVEVKQPEDRKPYLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEWEIHFAGQQTEFKILSLHPGQKYLVQVRCKPDHGYWSAWSPATFIQIPSDFTMNDTTVWISVAVLSAVICLIIVWAVALKGYSMVTCIFPPVPGPKIKGFDAHLLEKGKSEELLSALGCQDFPPTSDYEDLLVEYLEVDDSEDQHLMSVHSKEHPSQGMKPTYLDPDTDSGRGSCDSPSLLSEKCEEPQANPSTFYDPEVIEKPENPETTHTWDPQCISMEGKIPYFHAGGSKCSTWPLPQPSQHNPRSSYHNITDVCELAVGPAGAPATLLNEAGKDALKSSQTIKSREEGKATQQREVESFHSETDQDTPWLLPQEKTPFGSAKPLDYVEIHKVNKDGALSLLPKQRENSGKPKKPGTPENNKEYAKVSGVMDNNILVLVPDPHAKNVACFEESAKEAPPSLEQNQAEKALANFTATSSKCRLQLGGLDYLDPACFTHSFH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.
- Cross Reference Drug Bank:
- DB01185 DB00052
- Gene Ontology Go:
- cell surface
endosome lumen
extracellular region
integral component of membrane
plasma membrane
metal ion binding
ornithine decarboxylase activator activity
peptide hormone binding
prolactin receptor activity
protein homodimerization activity
activation of JAK2 kinase activity
activation of transmembrane receptor protein tyrosine kinase activity
cell surface receptor signaling pathway
embryo implantation
JAK-STAT cascade involved in growth hormone signaling pathway
lactation
mammary gland alveolus development
mammary gland epithelial cell differentiation
negative regulation of apoptotic process
prostate gland growth
regulation of cell adhesion
regulation of epithelial cell differentiation
steroid biosynthetic process
T cell activation - Gene Ontology Biological Process:
- activation of JAK2 kinase activity
activation of transmembrane receptor protein tyrosine kinase activity
cell surface receptor signaling pathway
embryo implantation
JAK-STAT cascade involved in growth hormone signaling pathway
lactation
mammary gland alveolus development
mammary gland epithelial cell differentiation
negative regulation of apoptotic process
prostate gland growth
regulation of cell adhesion
regulation of epithelial cell differentiation
steroid biosynthetic process
T cell activation - Gene Ontology Molecular Function:
- metal ion binding
ornithine decarboxylase activator activity
peptide hormone binding
prolactin receptor activity
protein homodimerization activity - Gene Ontology Cellular Component:
- cell surface
endosome lumen
extracellular region
integral component of membrane
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Membrane
Metal-binding
Polymorphism
Receptor
Reference proteome
Repeat
Secreted
Signal
Transmembrane
Transmembrane helix
Zinc - Interacts With:
- P01236; P63104