Names & Taxonomy
- Uniprot ID:
- P16233
- Entry Name:
- LIPP_HUMAN
- Status:
- reviewed
- Protein Names:
- Pancreatic triacylglycerol lipase (PL) (PTL) (Pancreatic lipase) (EC 3.1.1.3)
- Gene Names:
- PNLIP
- Gene Names Primary:
- PNLIP
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 465
- Sequence:
- MLPLWTLSLLLGAVAGKEVCYERLGCFSDDSPWSGITERPLHILPWSPKDVNTRFLLYTNENPNNFQEVAADSSSISGSNFKTNRKTRFIIHGFIDKGEENWLANVCKNLFKVESVNCICVDWKGGSRTGYTQASQNIRIVGAEVAYFVEFLQSAFGYSPSNVHVIGHSLGAHAAGEAGRRTNGTIGRITGLDPAEPCFQGTPELVRLDPSDAKFVDVIHTDGAPIVPNLGFGMSQVVGHLDFFPNGGVEMPGCKKNILSQIVDIDGIWEGTRDFAACNHLRSYKYYTDSIVNPDGFAGFPCASYNVFTANKCFPCPSGGCPQMGHYADRYPGKTNDVGQKFYLDTGDASNFARWRYKVSVTLSGKKVTGHILVSLFGNKGNSKQYEIFKGTLKPDSTHSNEFDSDVDVGDLQMVKFIWYNNVINPTLPRVGASKIIVETNVGKQFNFCSPETVREEVLLTLTPC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Catalytic Activity:
- Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
- Active Site:
- ACT_SITE 169 169 Nucleophile.; ACT_SITE 193 193 Charge relay system.; ACT_SITE 280 280 Charge relay system.
- Cross Reference Drug Bank:
- DB08909 DB01083
- Gene Ontology Go:
- extracellular region
metal ion binding
triglyceride lipase activity
fat-soluble vitamin metabolic process
intestinal cholesterol absorption
lipid catabolic process
lipid digestion
phototransduction, visible light
positive regulation of triglyceride lipase activity
retinoid metabolic process
small molecule metabolic process
vitamin metabolic process - Gene Ontology Biological Process:
- fat-soluble vitamin metabolic process
intestinal cholesterol absorption
lipid catabolic process
lipid digestion
phototransduction, visible light
positive regulation of triglyceride lipase activity
retinoid metabolic process
small molecule metabolic process
vitamin metabolic process - Gene Ontology Molecular Function:
- metal ion binding
triglyceride lipase activity - Gene Ontology Cellular Component:
- extracellular region
- Keywords:
- 3D-structure
Calcium
Complete proteome
Disulfide bond
Glycoprotein
Hydrolase
Lipid degradation
Lipid metabolism
Metal-binding
Reference proteome
Secreted
Signal