Names & Taxonomy

Uniprot ID:
P15586
Entry Name:
GNS_HUMAN
Status:
reviewed
Protein Names:
N-acetylglucosamine-6-sulfatase (EC 3.1.6.14) (Glucosamine-6-sulfatase) (G6S)
Gene Names:
GNS
Gene Names Primary:
GNS
Organism:
Homo sapiens (Human)

Structure

Length:
552
Sequence:
MRLLPLAPGRLRRGSPRHLPSCSPALLLLVLGGCLGVFGVAAGTRRPNVVLLLTDDQDEVLGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSKSWQKIQEPNTFPAILRSMCGYQTFFAGKYLNEYGAPDAGGLEHVPLGWSYWYALEKNSKYYNYTLSINGKARKHGENYSVDYLTDVLANVSLDFLDYKSNFEPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPRNKNFNIHGTNKHWLIRQAKTPMTNSSIQFLDNAFRKRWQTLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPIDKRQLYEFDIKVPLLVRGPGIKPNQTSKMLVANIDLGPTILDIAGYDLNKTQMDGMSLLPILRGASNLTWRSDVLVEYQGEGRNVTDPTCPSLSPGVSQCFPDCVCEDAYNNTYACVRTMSALWNLQYCEFDDQEVFVEVYNLTADPDQITNIAKTIDPELLGKMNYRLMMLQSCSGPTCRTPGVFDPGYRFDPRLMFSNRGSVRTRRFSKHLL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Lysosome.

Function

Catalytic Activity:
Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.
Cofactor:
COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
Gene Ontology Go:
extracellular exosome
lysosomal lumen
metal ion binding
N-acetylglucosamine-6-sulfatase activity
sulfuric ester hydrolase activity
carbohydrate metabolic process
glycosaminoglycan catabolic process
glycosaminoglycan metabolic process
keratan sulfate catabolic process
keratan sulfate metabolic process
small molecule metabolic process
Gene Ontology Biological Process:
carbohydrate metabolic process
glycosaminoglycan catabolic process
glycosaminoglycan metabolic process
keratan sulfate catabolic process
keratan sulfate metabolic process
small molecule metabolic process
Gene Ontology Molecular Function:
metal ion binding
N-acetylglucosamine-6-sulfatase activity
sulfuric ester hydrolase activity
Gene Ontology Cellular Component:
extracellular exosome
lysosomal lumen
Keywords:
Alternative splicing
Calcium
Complete proteome
Direct protein sequencing
Disease mutation
Glycoprotein
Hydrolase
Lysosome
Metal-binding
Mucopolysaccharidosis
Polymorphism
Reference proteome
Signal
Interacts With:
P16333

Publication

PubMed ID:
1463457 14702039 16541075 15489334 3196333 12754519 19159218 12573255 21269460 24275569 25944712 20232353