Names & Taxonomy
- Uniprot ID:
- P15309
- Entry Name:
- PPAP_HUMAN
- Status:
- reviewed
- Protein Names:
- Prostatic acid phosphatase (PAP) (EC 3.1.3.2) (5'-nucleotidase) (5'-NT) (EC 3.1.3.5) (Ecto-5'-nucleotidase) (Thiamine monophosphatase) (TMPase) [Cleaved into: PAPf39]
- Gene Names:
- ACPP
- Gene Names Primary:
- ACPP
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 386
- Sequence:
- MRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLVFRHGDRSPIDTFPTDPIKESSWPQGFGQLTQLGMEQHYELGEYIRKRYRKFLNESYKHEQVYIRSTDVDRTLMSAMTNLAALFPPEGVSIWNPILLWQPIPVHTVPLSEDQLLYLPFRNCPRFQELESETLKSEEFQKRLHPYKDFIATLGKLSGLHGQDLFGIWSKVYDPLYCESVHNFTLPSWATEDTMTKLRELSELSLLSLYGIHKQKEKSRLQGGVLVNEILNHMKRATQIPSYKKLIMYSAHDTTVSGLQMALDVYNGLLPPYASCHLTELYFEKGEYFVEMYYRNETQHEPYPLMLPGCSPSCPLERFAELVGPVIPQDWSTECMTTNSHQGTEDSTD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Secreted
Function
- Function:
- A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.; Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.
- Catalytic Activity:
- A phosphate monoester + H(2)O = an alcohol + phosphate.
- Enzyme Regulation:
- ENZYME REGULATION: Phosphatase activity inhibited by L(+)-tartrate, and by its derivative, alpha-benzylaminobenzylphosphonic acid.
- Active Site:
- ACT_SITE 44 44 Nucleophile.
- Cross Reference Drug Bank:
- DB06688
- Gene Ontology Go:
- apical part of cell
extracellular exosome
extracellular space
filopodium
Golgi cisterna
integral component of membrane
intracellular
lysosomal membrane
multivesicular body
nucleus
plasma membrane
secretory granule
vesicle membrane
5'-nucleotidase activity
acid phosphatase activity
choline binding
identical protein binding
lysophosphatidic acid phosphatase activity
phosphatase activity
thiamine phosphate phosphatase activity
adenosine metabolic process
dephosphorylation
nucleotide metabolic process
positive regulation of adenosine receptor signaling pathway
purine nucleobase metabolic process
regulation of sensory perception of pain
thiamine metabolic process - Gene Ontology Biological Process:
- adenosine metabolic process
dephosphorylation
nucleotide metabolic process
positive regulation of adenosine receptor signaling pathway
purine nucleobase metabolic process
regulation of sensory perception of pain
thiamine metabolic process - Gene Ontology Molecular Function:
- 5'-nucleotidase activity
acid phosphatase activity
choline binding
identical protein binding
lysophosphatidic acid phosphatase activity
phosphatase activity
thiamine phosphate phosphatase activity - Gene Ontology Cellular Component:
- apical part of cell
extracellular exosome
extracellular space
filopodium
Golgi cisterna
integral component of membrane
intracellular
lysosomal membrane
multivesicular body
nucleus
plasma membrane
secretory granule
vesicle membrane - Keywords:
- 3D-structure
Alternative splicing
Amyloid
Cell membrane
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Hydrolase
Lysosome
Membrane
Polymorphism
Reference proteome
Secreted
Signal - Interacts With:
- Itself