Names & Taxonomy
- Uniprot ID:
- P15289
- Entry Name:
- ARSA_HUMAN
- Status:
- reviewed
- Protein Names:
- Arylsulfatase A (ASA) (EC 3.1.6.8) (Cerebroside-sulfatase) [Cleaved into: Arylsulfatase A component B; Arylsulfatase A component C]
- Gene Names:
- ARSA
- Gene Names Primary:
- ARSA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 507
- Sequence:
- MGAPRSLLLALAAGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQICCHPGCTPRPACCHCPDPHA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Lysosome.
Function
- Function:
- Hydrolyzes cerebroside sulfate.
- Catalytic Activity:
- A cerebroside 3-sulfate + H(2)O = a cerebroside + sulfate.
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by phosphate. The phosphate forms a covalent bond with the active site 3-oxoalanine.
- Active Site:
- ACT_SITE 125 125
- Cross Reference Drug Bank:
- DB01141 DB04786
- Gene Ontology Go:
- endoplasmic reticulum lumen
extracellular exosome
lysosomal lumen
lysosome
arylsulfatase activity
calcium ion binding
cerebroside-sulfatase activity
sulfuric ester hydrolase activity
cellular protein metabolic process
glycosphingolipid metabolic process
post-translational protein modification
small molecule metabolic process
sphingolipid metabolic process - Gene Ontology Biological Process:
- cellular protein metabolic process
glycosphingolipid metabolic process
post-translational protein modification
small molecule metabolic process
sphingolipid metabolic process - Gene Ontology Molecular Function:
- arylsulfatase activity
calcium ion binding
cerebroside-sulfatase activity
sulfuric ester hydrolase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum lumen
extracellular exosome
lysosomal lumen
lysosome - Keywords:
- 3D-structure
Alternative splicing
Calcium
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Hydrolase
Ichthyosis
Leukodystrophy
Lysosome
Metachromatic leukodystrophy
Metal-binding
Polymorphism
Reference proteome
Signal - Interacts With:
- Q15645
Publication
- PubMed ID:
- 2562955 1975241 19262745 15461802 14702039 10591208 15489334 1352993 7628016 15146462 19159218 9521684 11124905 12888274 16368756 7866401 2574462 1673291 1678251 1670590 1353340 8101038 8101083 8095918 7902317 7906588 8104633 7909527 7825603 7860068 7581401 8891236 8723680 9272717 9090526 9490297 9600244 9744473 9452102 9819708 9888390 10220151 10477432 10533072 10381328 10751093 11061266 11020646 11456299 11941485 12503099 12788103 14517960 14680985 15326627 15026521 15710861 18693274 19606494 20339381 21265945