Names & Taxonomy
- Uniprot ID:
- P15170
- Entry Name:
- ERF3A_HUMAN
- Status:
- reviewed
- Protein Names:
- Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (Eukaryotic peptide chain release factor subunit 3a) (eRF3a) (G1 to S phase transition protein 1 homolog)
- Gene Names:
- GSPT1 ERF3A
- Gene Names Primary:
- GSPT1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 499
- Sequence:
- MELSEPIVENGETEMSPEESWEHKEEISEAEPGGGSLGDGRPPEESAHEMMEEEEEIPKPKSVVAPPGAPKKEHVNVVFIGHVDAGKSTIGGQIMYLTGMVDKRTLEKYEREAKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLINKMDDPTVNWSNERYEECKEKLVPFLKKVGFNPKKDIHFMPCSGLTGANLKEQSDFCPWYIGLPFIPYLDNLPNFNRSVDGPIRLPIVDKYKDMGTVVLGKLESGSICKGQQLVMMPNKHNVEVLGILSDDVETDTVAPGENLKIRLKGIEEEEILPGFILCDPNNLCHSGRTFDAQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALICLVDKKSGEKSKTRPRFVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLVPEKD
- Proteomes:
- UP000005640
Function
- Function:
- Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ERF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.
- Gene Ontology Go:
- cytosol
intracellular
translation release factor complex
GTP binding
GTPase activity
poly(A) RNA binding
translation release factor activity
cytoplasmic translational termination
G1/S transition of mitotic cell cycle
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
protein methylation - Gene Ontology Biological Process:
- cytoplasmic translational termination
G1/S transition of mitotic cell cycle
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
protein methylation - Gene Ontology Molecular Function:
- GTPase activity
GTP binding
poly(A) RNA binding
translation release factor activity - Gene Ontology Cellular Component:
- cytosol
intracellular
translation release factor complex - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
GTP-binding
Nonsense-mediated mRNA decay
Nucleotide-binding
Protein biosynthesis
Reference proteome - Interacts With:
- P62495; P11940; Q92900